(S)-cyclohexyl-[6-(2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

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Chemical Name:(S)-cyclohexyl-[6-(2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone
CAS No.:1055947-81-3
Molecular Formula:C₂₆H₃₇N₃O₂
Molecular Weight:423.599
Hs Code.:

Synonyms:(S)-cyclohexyl-[6-(2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-cyclohexyl-[6-(2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-cyclohexyl-[6-(2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

There total 4 articles about (S)-cyclohexyl-[6-(2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1055948-77-0
2-cyclohexanecarbonyl-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid

: 51207-66-0
(S)-2-(1-pyrrolidinylmethyl)pyrrolidine

: 1055947-81-3
(S)-cyclohexyl-[6-(2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 24h;

Reference yield:

: 185057-00-5
methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate

: 1055947-81-3
(S)-cyclohexyl-[6-(2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: potassium hydroxide; water; isopropyl alcohol / 20 h / 80 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h

With potassium hydroxide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isopropyl alcohol; In dichloromethane;

Reference yield:

: 1055948-76-9
2-cyclohexanecarbonyl-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid methyl ester

: 1055947-81-3
(S)-cyclohexyl-[6-(2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; water; isopropyl alcohol / 20 h / 80 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h

With potassium hydroxide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropyl alcohol; In dichloromethane;