METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLATE

Base Information

Chemical Name:METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLATE
CAS No.:185057-00-5
Molecular Formula:C11H13NO2
Molecular Weight:191.23
Hs Code.:2933499090
Mol file:185057-00-5.mol

Synonyms:1,2,3,4-Tetrahydroisoquinoline-6-carboxylicacid methyl ester;Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate;

Suppliers and Price of METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
1,2,3,4-Tetrahydro-isoquinoline-6-carboxylicacidmethylester 97%
5g
$ 1590.00

J&W Pharmlab
1,2,3,4-Tetrahydro-isoquinoline-6-carboxylicacidmethylester 97%
50mg
$ 117.00

Crysdot
Methyl1,2,3,4-tetrahydroisoquinoline-6-carboxylate 95+%
1g
$ 713.00

Chemenu
1,2,3,4-Tetrahydro-isoquinoline-6-carboxylicacidmethylester 95%
1g
$ 673.00

Atlantic Research Chemicals
Methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate 95%
1gm:
$ 215.61

American Custom Chemicals Corporation
METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLATE 95.00%
5MG
$ 504.89

Alichem
Methyl1,2,3,4-tetrahydroisoquinoline-6-carboxylate
1g
$ 720.00

Total 21 raw suppliers

Chemical Property of METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLATE

Chemical Property:

Boiling Point:330.2 °C at 760 mmHg
PKA:8.74±0.20(Predicted)
Flash Point:153.5 °C
PSA：38.33000
Density:1.123 g/cm³
LogP:1.44770
Storage Temp.:2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

1,2,3,4-Tetrahydro-isoquinoline-6-carboxylicacidmethylester 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 25-36/37/38
Safety Statements: 26-45

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLATE

There total 6 articles about METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 173089-82-2
isoquinoline-6-carboxylic acid methyl ester

: 185057-00-5
methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate

Guidance literature:: With platinum(IV) oxide; hydrogen; acetic acid; In methanol; at 20 ℃; for 6h;
DOI:10.1016/j.ejmech.2018.12.065

Reference yield:

: 34784-05-9
6-bromo-isoquinoline

: 185057-00-5
methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; palladium diacetate; sodium acetate / N,N-dimethyl-formamide / 15 h / 100 °C / 2250.23 Torr / Autoclave

2: platinum(IV) oxide; acetic acid; hydrogen / methanol / 3 h / 40 °C / Inert atmosphere

With platinum(IV) oxide; hydrogen; sodium acetate; palladium diacetate; acetic acid; triphenylphosphine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 106778-42-1
isoquinoline-6-carbonitrile

: 185057-00-5
methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; water / ethanol / 12 h / Reflux

1.2: 4 h / Reflux

2.1: acetic acid; platinum(IV) oxide; hydrogen / methanol / 6 h / 20 °C

With platinum(IV) oxide; water; hydrogen; acetic acid; potassium hydroxide; In methanol; ethanol;
DOI:10.1016/j.ejmech.2018.12.065