185057-00-5

Usage

Uses

Used in Organic Chemistry:
METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLATE is used as a synthetic intermediate for the preparation of various organic compounds. Its carboxylate and methyl ester groups provide opportunities for nucleophilic substitution reactions, making it a versatile building block in the synthesis of complex molecules.
Used in Medical Chemistry:
In the field of medical chemistry, METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLATE is used as a precursor for the development of biologically active compounds. The carboxylate group at the 6-position is a common motif in many pharmaceuticals, allowing for the creation of molecules with potential therapeutic applications. Its reactivity and solubility properties make it an attractive candidate for drug design and optimization.

Upstream product

• 106778-43-2 isoquinoline-6-carboxylic acid 
• 1245798-39-3 methyl 1-oxo-1,2,3,4-tetrahydroisoquinoline-6-carboxylate 
• 106778-42-1 isoquinoline-6-carbonitrile 
• 173089-82-2 isoquinoline-6-carboxylic acid methyl ester 
• 34784-05-9 6-bromo-isoquinoline 

Downstream Products

• 860457-96-1 2-(1-Phenyl-ethyl)-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid 
• 1055948-76-9 2-cyclohexanecarbonyl-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid methyl ester 
• 1055948-93-0 2-cyclohexanecarbonyl-1,2,3,4-tetrahydro-isoquinoline-6-carbaldehyde 
• 1055948-92-9 cyclohexyl-(6-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone 
• 1055948-77-0 2-cyclohexanecarbonyl-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid 
• 1055948-08-7 cyclohexyl-(6-piperidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone 
• 1055947-81-3 (S)-cyclohexyl-[6-(2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone 

Relevant academic research and scientific papers

Quinoline and Isoquinoline Based HDAC Inhibitors and Methods of Use Thereof

The present invention relates to methods of modulating activity of histone deacetylases (HDACs). The present invention also relates to methods of treating HDAC-associated diseases including, but not limited to, cancers, inflammatory disorders, and neurode

Azacyclic derivative as well as preparation method and medical use thereof

The invention relates to an azacyclic derivative as well as a preparation method and medical use thereof and particularly relates to an azacyclic derivative represented by a general formula (I) (shownin the description), a preparation method thereof, a pharmaceutical composition containing the derivative and use of the derivative as an SMO antagonist, particularly in the treatment of diseases such as cancer related to Hedgehog signal channels. The definitions of groups in the general formula (I) are same as the definitions in the description.

Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation

Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a series of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)amide derivatives targeting PRMT5 were designed with structure-based approach and synthesized. Among them, compound 46 showed potent and selective PRMT5 inhibition activity with an IC50 of 8.5 nM, which was approximately equivalent with the phase I clinical trial PRMT5 inhibitor GSK-3326595 (IC50 = 5.5 nM). Compound 46 also displayed pronounced anti-proliferative activity in MV4-11 cells (GI50 = 18 nM) and antitumor activity in MV4-11 mouse xenografts model. This molecule can serve as an excellent tool compound for probing the biological function of PRMT5.

PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST

The present invention relates to a pyrrolopyrimidine compound as TLR7 agonist, and particularly relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, a preparation process thereof, a pharmaceutical composition containing such compounds and use thereof for manufacturing a medicament against viral infection.

Pyrrolo pyrimidine ring compound, its use and pharmaceutical composition (by machine translation)

The invention relates to an as TLR7 agonist of the pyrrolo pyrimidine compounds, specifically on a compound of formula (I) compound or its pharmaceutically acceptable salt, preparation method thereof, containing the compounds of the pharmaceutical composition, and its use for the preparation of antiviral drug use. Formula (I) (by machine translation)

Dipeptides which promote release of growth hormone

Compounds of formula (I) are growth hormone releasing peptide mimetics which are useful for the treatment and prevention of osteoporosis. STR1