4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate

Base Information

• Chemical Name: 4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate
• CAS No.: 1192797-38-8
• Molecular Formula: C₁₆H₂₅NO₅S
• Molecular Weight: 343.444
• Mol file: 1192797-38-8.mol

Synonyms:4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate

Chemical Property of 4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate

There total 3 articles about 4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 4-(4-hydroxybutyl)phenylcarbamate (1192797-36-6) + methanesulfonyl chloride (124-63-0) → 4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate (1192797-38-8)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1071/CH09308

Reference yield:

4-(4-nitrophenyl)-1-butanol (79524-20-2) → 4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate (1192797-38-8)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium on carbon; hydrogen

2: tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

3: triethylamine / dichloromethane

With palladium on carbon; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1071/CH09308

Reference yield:

4-(p-aminophenyl)butanol (91251-45-5) → 4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate (1192797-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

2: triethylamine / dichloromethane

With triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1071/CH09308

upstream raw materials:

tert-butyl 4-(4-hydroxybutyl)phenylcarbamate

methanesulfonyl chloride

4-(p-aminophenyl)butanol

4-(4-nitrophenyl)-1-butanol

Downstream raw materials:

4-(4-aminophenyl)butyl ethanethioate