4-(4-aminophenyl)butyl ethanethioate

Base Information

• Chemical Name: 4-(4-aminophenyl)butyl ethanethioate
• CAS No.: 125428-44-6
• Molecular Formula: C₁₂H₁₇NOS
• Molecular Weight: 223.339
• Mol file: 125428-44-6.mol

Synonyms:4-(4-aminophenyl)butyl ethanethioate

Chemical Property of 4-(4-aminophenyl)butyl ethanethioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-aminophenyl)butyl ethanethioate

There total 5 articles about 4-(4-aminophenyl)butyl ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-[4-(tert-butoxycarbonylamino)phenyl]butyl ethanethioate (1192797-40-2) → 4-(4-aminophenyl)butyl ethanethioate (125428-44-6)

Guidance literature:

With tetrafluoroboric acid; trifluoroacetic acid; In dichloromethane; at 20 - 35 ℃; for 24h;

DOI:10.1071/CH09308

Reference yield:

4-(4-nitrophenyl)-1-butanol (79524-20-2) → 4-(4-aminophenyl)butyl ethanethioate (125428-44-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: palladium on carbon; hydrogen

2.1: tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

3.1: triethylamine / dichloromethane

4.1: potassium tert-butylate / N,N-dimethyl-formamide

4.2: 48 h / 20 °C

5.1: tetrafluoroboric acid; trifluoroacetic acid / dichloromethane / 24 h / 20 - 35 °C

With tetrafluoroboric acid; palladium on carbon; potassium tert-butylate; hydrogen; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1071/CH09308

Reference yield:

4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate (1192797-38-8) → 4-(4-aminophenyl)butyl ethanethioate (125428-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide

1.2: 48 h / 20 °C

2.1: tetrafluoroboric acid; trifluoroacetic acid / dichloromethane / 24 h / 20 - 35 °C

With tetrafluoroboric acid; potassium tert-butylate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1071/CH09308

upstream raw materials:

4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate

4-[4-(tert-butoxycarbonylamino)phenyl]butyl ethanethioate

tert-butyl 4-(4-hydroxybutyl)phenylcarbamate

4-(p-aminophenyl)butanol

Downstream raw materials:

4-(4-aminophenyl)-1-butanethiol