phenyl 2-(6-amino-3,4-dihydroquinolin-1(2H)-yl)ethyl(methyl)carbamate

Base Information

• Chemical Name: phenyl 2-(6-amino-3,4-dihydroquinolin-1(2H)-yl)ethyl(methyl)carbamate
• CAS No.: 1063407-55-5
• Molecular Formula: C₁₉H₂₃N₃O₂
• Molecular Weight: 325.411
• Mol file: 1063407-55-5.mol

Synonyms:phenyl 2-(6-amino-3,4-dihydroquinolin-1(2H)-yl)ethyl(methyl)carbamate

Chemical Property of phenyl 2-(6-amino-3,4-dihydroquinolin-1(2H)-yl)ethyl(methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl 2-(6-amino-3,4-dihydroquinolin-1(2H)-yl)ethyl(methyl)carbamate

There total 2 articles about phenyl 2-(6-amino-3,4-dihydroquinolin-1(2H)-yl)ethyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-2-(6-nitro-3,4-dihydroquinolin-1(2H)-yl)ethanamine (1063407-52-2) → phenyl 2-(6-amino-3,4-dihydroquinolin-1(2H)-yl)ethyl(methyl)carbamate (1063407-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 17 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 4.5 h / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm3000449

Reference yield:

phenyl chloroformate (1885-14-9) → phenyl 2-(6-amino-3,4-dihydroquinolin-1(2H)-yl)ethyl(methyl)carbamate (1063407-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 17 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 4.5 h / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm3000449

Reference yield: 67.2%

phenyl 2-(6-amino-3,4-dihydroquinolin-1(2H)-yl)ethyl(methyl)carbamate (1063407-55-5) + methyl thiophene-2-carbimidothioate hydroiodide → phenyl methyl(2-(6-(thiophene-2-carboximidamido)-3,4-dihydroquinolin-1(2H)-yl)ethyl)carbamate (1063407-57-7)

Guidance literature:

phenyl 2-(6-amino-3,4-dihydroquinolin-1(2H)-yl)ethyl(methyl)carbamate; methyl thiophene-2-carbimidothioate hydroiodide; In ethanol; at 20 ℃;

With water; sodium carbonate; In ethanol; dichloromethane;

upstream raw materials:

N,N-dimethyl-2-(6-nitro-3,4-dihydroquinolin-1(2H)-yl)ethanamine

phenyl chloroformate

Downstream raw materials:

phenyl methyl(2-(6-(thiophene-2-carboximidamido)-3,4-dihydroquinolin-1(2H)-yl)ethyl)carbamate