N-methylnaphthalen-1-amine

Base Information

• Chemical Name: N-methylnaphthalen-1-amine
• CAS No.: 2216-68-4
• Molecular Formula: C11H11 N
• Molecular Weight: 157.215
• Hs Code.: 2921450090
• European Community (EC) Number: 218-695-6
• NSC Number: 9412
• UNII: GBT9LV0NVR
• DSSTox Substance ID: DTXSID0062262
• Nikkaji Number: J54.248B
• Wikidata: Q72493283
• Mol file: 2216-68-4.mol

Synonyms:N-methylnaphthalen-1-amine;2216-68-4;N-Methyl-N-1-naphthylamine;N-Methyl-1-naphthylamine;1-Naphthalenamine, N-methyl-;1-Methylaminonaphthalene;1-Naphthylamine, N-methyl;Methyl(1-naphthyl)amine;N-Methyl-1-naftylamin;N-Methyl-alpha-naphthylamine;Methyl-naphthalen-1-yl-amine;N-Methyl-.alpha.-naphthylamine;N-Methyl-1-naftylamin [Czech];GBT9LV0NVR;1-NAPHTHYLAMINE, N-METHYL-;NSC 9412;EINECS 218-695-6;BRN 0508492;NSC-9412;MFCD00972770;n-methyl-n-naphthylamine;NSC9412;methylaminonaphthalene;Ethylhexanoicacidzincsalt;UNII-GBT9LV0NVR;N-Methyl-1-naphthalenamine;naphthalen-1-yl-methylamine;SCHEMBL49308;WLN: L66J BM1;N-Methyl-1-naphthalenamine #;n-methyl-n-(1-naphthyl)amine;SCHEMBL6059156;DTXSID0062262;N-(1-NAPHTHYL)METHYLAMINE;1-(METHYLAMINO)NAPHTHALENE;N-METHYLNAPHTHALENE-1-AMINE;AKOS000251907;CS-W005609;FS-2617;LS-95737;SY042924;FT-0634139;EN300-53852;A878670;Z335254222

Chemical Property of N-methylnaphthalen-1-amine

Chemical Property:

• Vapor Pressure: 0.00177mmHg at 25°C
• Melting Point: 174°C
• Refractive Index: 1.6722 (estimate)
• Boiling Point: 293°C at 760 mmHg
• PKA: 3.67(at 27℃)
• Flash Point: 140.7°C
• PSA: 12.03000
• Density: 1.099g/cm³
• LogP: 2.95450
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 157.089149355
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

97% ^*data from raw suppliers

N-Methyl-N-1-naphthylamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=CC=CC2=CC=CC=C21

Technology Process of N-methylnaphthalen-1-amine

There total 51 articles about N-methylnaphthalen-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-amino-naphthalene (134-32-7) + acetic acid (64-19-7,77671-22-8) → N-methylnaphthalen-1-amine (2216-68-4)

Guidance literature:

With 9-(2-chlorophenyl)acridine; bis(1-methyl-1-phenylethyl)peroxide; copper(II) hexafluoroacetylacetonate; In ethyl acetate; at 35 ℃; for 24h; Inert atmosphere; Irradiation;

DOI:10.1002/anie.201916710

Reference yield: 97.0%

methylamine hydrochloride (593-51-1) + 1-Chloronaphthalene (90-13-1) → N-methylnaphthalen-1-amine (2216-68-4)

Guidance literature:

With (R)-(-)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; bis(tri-ortho-tolylphosphine)palladium⁽⁰⁾; sodium t-butanolate; In 1,4-dioxane; at 100 ℃; for 12h; Inert atmosphere; Glovebox;

DOI:10.1021/ol501739g

Reference yield: 90.0%

C19H17NO2 → N-methylnaphthalen-1-amine (2216-68-4)

Guidance literature:

With methylmagnesium bromide; hydrogen; palladium diacetate; nickel diacetate; In water; at 45 ℃; for 20h;

DOI:10.1021/acscatal.9b02316

upstream raw materials:

methyl magnesium iodide

1-Nitronaphthalene

1-naphthylformamide

N-(1-naphthyl)-N-methyl cyanamide

Downstream raw materials:

N-methyl-N-(naphthalen-1-yl)acetamide

methyl-[1]naphthyl-amine; compound with picryl chloride

2-benzyl-N-methyl-1-naphthylamine

N,4-dimethyl-N-(naphthalen-1-yl)benzenesulfonamide