dimethyl 2-(4-(2-((tert-butoxycarbonyl)amino)ethoxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate

Base Information

Chemical Name:dimethyl 2-(4-(2-((tert-butoxycarbonyl)amino)ethoxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate
CAS No.:1420039-70-8
Molecular Formula:C₃₂H₅₁NO₈Si
Molecular Weight:605.844
Hs Code.:

Synonyms:dimethyl 2-(4-(2-((tert-butoxycarbonyl)amino)ethoxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate

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Chemical Property of dimethyl 2-(4-(2-((tert-butoxycarbonyl)amino)ethoxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate

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Technology Process of dimethyl 2-(4-(2-((tert-butoxycarbonyl)amino)ethoxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate

There total 16 articles about dimethyl 2-(4-(2-((tert-butoxycarbonyl)amino)ethoxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 39684-80-5
2-(tert-butoxycarbonylamino)ethyl bromide

: 1420039-68-4
dimethyl 2-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-3-(4-hydroxybenzyl)maleate

: 1420039-70-8
dimethyl 2-(4-(2-((tert-butoxycarbonyl)amino)ethoxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 19h;

Reference yield:

: 31770-76-0
3-(4-hydroxyphenyl)propionic acid benzyl ester

: 1420039-70-8
dimethyl 2-(4-(2-((tert-butoxycarbonyl)amino)ethoxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / dichloromethane / 15 h / 0 - 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C / Inert atmosphere

2.2: 1 h / -78 °C

3.1: palladium 10% on activated carbon; hydrogen / 24 h / Inert atmosphere

4.1: acetic anhydride / 18 h / 120 °C

5.1: methanol; diethyl ether / 5 h / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 0 - 20 °C

7.1: caesium carbonate / N,N-dimethyl-formamide / 19 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; acetic anhydride; caesium carbonate; diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 1420039-70-8
dimethyl 2-(4-(2-((tert-butoxycarbonyl)amino)ethoxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 15 h

2.1: 1H-imidazole / dichloromethane / 15 h / 0 - 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C / Inert atmosphere

3.2: 1 h / -78 °C

4.1: palladium 10% on activated carbon; hydrogen / 24 h / Inert atmosphere

5.1: acetic anhydride / 18 h / 120 °C

6.1: methanol; diethyl ether / 5 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 0 - 20 °C

8.1: caesium carbonate / N,N-dimethyl-formamide / 19 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; acetic anhydride; potassium carbonate; caesium carbonate; diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;