N,N-bis<2-amino>ethyl>-4-nitro-L-phenylalanine benzyl ester

Base Information

• Chemical Name: N,N-bis<2-amino>ethyl>-4-nitro-L-phenylalanine benzyl ester
• CAS No.: 146432-47-5
• Molecular Formula: C₄₄H₆₆N₄O₁₂
• Molecular Weight: 843.028
• Mol file: 146432-47-5.mol

Synonyms:N,N-bis<2-amino>ethyl>-4-nitro-L-phenylalanine benzyl ester

Chemical Property of N,N-bis<2-amino>ethyl>-4-nitro-L-phenylalanine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-bis<2-amino>ethyl>-4-nitro-L-phenylalanine benzyl ester

There total 6 articles about N,N-bis<2-amino>ethyl>-4-nitro-L-phenylalanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

N-(2-bromoethyl)-N-[2-(1,1-dimethylethoxy)-2-oxoethyl]glycine 1,1-dimethylethyl ester (146432-43-1) + p-nitro-L-phenylalanine benzyl ester toluene-p-sulfonate → N,N-bis<2-amino>ethyl>-4-nitro-L-phenylalanine benzyl ester (146432-47-5) + N-<2-amino>ethyl>-4-nitro-L-phenylalanine benzyl ester (146432-45-3)

Guidance literature:

With phosphate buffer; In acetonitrile; for 22h; Ambient temperature;

DOI:10.1021/jo00057a030

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → N,N-bis<2-amino>ethyl>-4-nitro-L-phenylalanine benzyl ester (146432-47-5)

Guidance literature:

Multi-step reaction with 3 steps

1: KHCO₃ / dimethylformamide / 1) 0 deg C, 2) r.t.

2: NBS, Ph₃P / CH₂Cl₂ / 0 °C

3: 59 percent / phosphate buffer (pH 8) / acetonitrile / 22 h / Ambient temperature

With N-Bromosuccinimide; phosphate buffer; potassium hydrogencarbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo00057a030

Reference yield:

4-nitro-3-phenyl-L-alanine (949-99-5) → N,N-bis<2-amino>ethyl>-4-nitro-L-phenylalanine benzyl ester (146432-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 10 h / Heating

2: 59 percent / phosphate buffer (pH 8) / acetonitrile / 22 h / Ambient temperature

With phosphate buffer; In acetonitrile; benzene;

DOI:10.1021/jo00057a030

upstream raw materials:

N-(2-bromoethyl)-N-[2-(1,1-dimethylethoxy)-2-oxoethyl]glycine 1,1-dimethylethyl ester

bromoacetic acid tert-butyl ester

4-nitro-3-phenyl-L-alanine

[tert-Butoxycarbonylmethyl-(2-hydroxy-ethyl)-amino]-acetic acid tert-butyl ester