N,N-BIS(T-BUTYL-4-CARBOXYMETHYL)AMINOETHANOL

Base Information

• Chemical Name: N,N-BIS(T-BUTYL-4-CARBOXYMETHYL)AMINOETHANOL
• CAS No.: 146432-41-9
• Molecular Formula: C14H27NO5
• Molecular Weight: 289.36800
• Mol file: 146432-41-9.mol

Synonyms:di;N,N-BIS(T-BUTYL-4-CARBOXYMETHYL)AMINOETHANOL;N-[2-(1,1-dimethylethoxy)-2-oxoethyl]-N-(2-hydroxyethyl)glycine 1,1-dimethylethyl ester;

Chemical Property of N,N-BIS(T-BUTYL-4-CARBOXYMETHYL)AMINOETHANOL

Chemical Property:

• PSA: 76.07000
• LogP: 0.96410

Purity/Quality:

N,N-BIS-(TERT-BUTYL-4-CARBOXYMETHYL)AMINOETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-BIS(T-BUTYL-4-CARBOXYMETHYL)AMINOETHANOL

There total 2 articles about N,N-BIS(T-BUTYL-4-CARBOXYMETHYL)AMINOETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

bromoacetic acid tert-butyl ester (5292-43-3) + ethanolamine (141-43-5) → [tert-Butoxycarbonylmethyl-(2-hydroxy-ethyl)-amino]-acetic acid tert-butyl ester (146432-41-9)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/ic3017613

Reference yield:

glycolaldehyde dimer (23147-58-2,110822-84-9,110822-85-0,77431-49-3) + tert-butyl iminodiacetate (85916-13-8) → [tert-Butoxycarbonylmethyl-(2-hydroxy-ethyl)-amino]-acetic acid tert-butyl ester (146432-41-9)

Guidance literature:

glycolaldehyde dimer; tert-butyl iminodiacetate; With sodium cyanoborohydride; In acetonitrile; for 0.166667h;

With acetic acid; In acetonitrile; for 1.5h;

Reference yield: 79.0%

[tert-Butoxycarbonylmethyl-(2-hydroxy-ethyl)-amino]-acetic acid tert-butyl ester (146432-41-9) + benzyl (S)-2-isocyanato-3-(4-nitrophenyl)propionate → N-<<2-amino>ethoxy>carbonyl>-4-nitro-L-phenylalanine benzyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 36h; Ambient temperature;

DOI:10.1021/jo00057a030

upstream raw materials:

bromoacetic acid tert-butyl ester

ethanolamine

glycolaldehyde dimer

tert-butyl iminodiacetate

Downstream raw materials:

N-(2-bromoethyl)-N-[2-(1,1-dimethylethoxy)-2-oxoethyl]glycine 1,1-dimethylethyl ester

{carboxymethyl-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-amino}-acetic acid; compound with toluene-4-sulfonic acid

N,N-bis[2-[N',N'-bis[(tert-butoxycarbonyl)methyl]amino]ethyl]-L-aspartic acid, benzyl ester

N,N-bis<2-amino>ethyl>-4-nitro-L-phenylalanine benzyl ester