4-(p-nitrophenyl)butan-2-one ethylene ketal

Base Information

Chemical Name:4-(p-nitrophenyl)butan-2-one ethylene ketal
CAS No.:1272975-51-5
Molecular Formula:C₁₂H₁₅NO₄
Molecular Weight:237.255
Hs Code.:

Synonyms:4-(p-nitrophenyl)butan-2-one ethylene ketal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(p-nitrophenyl)butan-2-one ethylene ketal

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Technology Process of 4-(p-nitrophenyl)butan-2-one ethylene ketal

There total 5 articles about 4-(p-nitrophenyl)butan-2-one ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30780-19-9
4-(4-nitrophenyl)butan-2-one

: 107-21-1
ethylene glycol

: 1272975-51-5
4-(p-nitrophenyl)butan-2-one ethylene ketal

Guidance literature:: With camphor-10-sulfonic acid; In toluene; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2010.12.045

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1272975-51-5
4-(p-nitrophenyl)butan-2-one ethylene ketal

Guidance literature:: Multi-step reaction with 2 steps

1: lithium diisopropyl amide / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / -78 °C

2: toluene-4-sulfonic acid / tetrahydrofuran / Molecular sieve

With toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/j.tetlet.2012.01.016

Reference yield:

: 107324-93-6
3-(p-nitrophenyl)propanoyl chloride

: 1272975-51-5
4-(p-nitrophenyl)butan-2-one ethylene ketal

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; 2-methyltetrahydrofuran / -20 °C

1.2: 0 - 20 °C

2.1: toluene-4-sulfonic acid / toluene / 65 - 80 °C

3.1: toluene-4-sulfonic acid / tetrahydrofuran / Molecular sieve

With toluene-4-sulfonic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 2-methyltetrahydrofuran; toluene;
DOI:10.1016/j.tetlet.2012.01.016