2'-deoxy-2'-(3-methoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine

Base Information

• Chemical Name: 2'-deoxy-2'-(3-methoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine
• CAS No.: 160056-65-5
• Molecular Formula: C₃₀H₄₆N₆O₆Si₂
• Molecular Weight: 642.903

Synonyms:2'-deoxy-2'-(3-methoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine

Chemical Property of 2'-deoxy-2'-(3-methoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine

Chemical Property:

Purity/Quality:

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Technology Process of 2'-deoxy-2'-(3-methoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine

There total 4 articles about 2'-deoxy-2'-(3-methoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

m-anisoyl chloride (1711-05-3) + 2'-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine (160056-49-5) → 2'-deoxy-2'-(3-methoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine (160056-65-5)

Guidance literature:

With pyridine; In dichloromethane; for 3h; Heating;

DOI:10.1021/jm9802620

Reference yield: 61.0%

3-Methoxybenzoic acid (586-38-9) + 2'-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine (160056-49-5) → 2'-deoxy-2'-(3-methoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine (160056-65-5)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1002/hlca.19940770306

Reference yield:

3-Methoxybenzoic acid (586-38-9) → 2'-deoxy-2'-(3-methoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine (160056-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₅ / CH₂Cl₂ / 5 h / Ambient temperature

2: 77 percent / pyridine / CH₂Cl₂ / 3 h / Heating

With pyridine; phosphorus pentachloride; In dichloromethane;

DOI:10.1021/jm9802620

upstream raw materials:

3-Methoxybenzoic acid

2'-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine

m-anisoyl chloride

2'?azido?2'?deoxy?3',5'?O?(1,1,3,3?tetraisopropyldisiloxane?1,3?diyl)adenosine

Downstream raw materials:

N-{(2R,3R,3aS,9aR)-2-[6-(2,5-Dimethyl-benzylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl}-3-methoxy-benzamide

N-{(2R,3R,3aS,9aR)-2-[6-(2,3-Dimethyl-benzylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl}-3-methoxy-benzamide

N⁶-benzyl-2'-deoxy-2'-(3-methoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine

N⁶-benzyl-2'-deoxy-2'-(3-methoxybenzamido)adenosine

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