5-chloro-pyridine-2-carboxylic acid [3-((S)-6-amino-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-8-yl)-4-fluoro-phenyl]-amide

Base Information

Chemical Name:5-chloro-pyridine-2-carboxylic acid [3-((S)-6-amino-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-8-yl)-4-fluoro-phenyl]-amide
CAS No.:1310373-79-5
Molecular Formula:C₁₉H₁₈ClFN₄O₂
Molecular Weight:388.829
Hs Code.:

Synonyms:5-chloro-pyridine-2-carboxylic acid [3-((S)-6-amino-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-8-yl)-4-fluoro-phenyl]-amide

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Chemical Property of 5-chloro-pyridine-2-carboxylic acid [3-((S)-6-amino-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-8-yl)-4-fluoro-phenyl]-amide

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Technology Process of 5-chloro-pyridine-2-carboxylic acid [3-((S)-6-amino-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-8-yl)-4-fluoro-phenyl]-amide

There total 8 articles about 5-chloro-pyridine-2-carboxylic acid [3-((S)-6-amino-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-8-yl)-4-fluoro-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86873-60-1
5-chloropicolinic acid

: 1310374-18-5
(S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine

: 1310373-79-5
5-chloro-pyridine-2-carboxylic acid [3-((S)-6-amino-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-8-yl)-4-fluoro-phenyl]-amide

Guidance literature:: 5-chloropicolinic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 0 ℃; for 1h;

(S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine; In methanol; at 0 ℃; for 24h;

Reference yield:

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1310373-79-5
5-chloro-pyridine-2-carboxylic acid [3-((S)-6-amino-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-8-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

2.2: 4 h

3.1: hydrogenchloride / ethyl acetate / 5.5 h / 65 °C / Sealed tube

4.1: borane-THF / tetrahydrofuran / 3 h / 0 °C

5.1: sodium acetate / tetrahydrofuran / 80 °C

5.2: 1 h / 22 °C

6.1: triethylamine; hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 22 °C / 760.05 Torr

7.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 1 h / 0 °C

7.2: 24 h / 0 °C

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; borane-THF; hydrogen; sodium acetate; triethylamine; diisopropylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; hexane; ethyl acetate;

Reference yield:

: 1075231-40-1
1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester

: 1310373-79-5
5-chloro-pyridine-2-carboxylic acid [3-((S)-6-amino-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-8-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethyl acetate / 5.5 h / 65 °C / Sealed tube

2.1: borane-THF / tetrahydrofuran / 3 h / 0 °C

3.1: sodium acetate / tetrahydrofuran / 80 °C

3.2: 1 h / 22 °C

4.1: triethylamine; hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 22 °C / 760.05 Torr

5.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 1 h / 0 °C

5.2: 24 h / 0 °C

With hydrogenchloride; borane-THF; hydrogen; sodium acetate; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; ethyl acetate;