1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: 1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester
• CAS No.: 1075231-40-1
• Molecular Formula: C₂₀H₂₉FN₂O₅S
• Molecular Weight: 428.525
• Mol file: 1075231-40-1.mol

Synonyms:1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester

Chemical Property of 1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester

There total 3 articles about 1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide (1075230-62-4) + tert-butyl cyclopropanecarboxylate (87661-20-9) → 1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester (1075231-40-1)

Guidance literature:

tert-butyl cyclopropanecarboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 4h;

(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide; In tetrahydrofuran; hexane; for 4h;

With water; In tetrahydrofuran; hexane;

Reference yield:

(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide (1076160-56-9) + tert-butyl cyclopropanecarboxylate (87661-20-9) → 1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester (1075231-40-1)

Guidance literature:

tert-butyl cyclopropanecarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; Cooling with acetone-dry ice;

With triisopropoxytitanium(IV) chloride; In tetrahydrofuran; n-heptane; ethylbenzene;

(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; n-heptane; ethylbenzene;

Reference yield:

1-(2-fluoro-5-nitrophenyl)ethanone (79110-05-7) → 1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester (1075231-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

2.2: 4 h

With titanium(IV) tetraethanolate; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane;

upstream raw materials:

(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide

tert-butyl cyclopropanecarboxylate

(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide

1-(2-fluoro-5-nitrophenyl)ethanone

Downstream raw materials:

1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt

{1-[(S)-1-amino-1-(2-fluoro-5-nitro-phenyl)-ethyl]-cyclopropyl}-methanol

(S)-8-(2-fluoro-5-nitro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine

(S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine