(S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine

Base Information

Chemical Name:(S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine
CAS No.:1310374-18-5
Molecular Formula:C₁₃H₁₆FN₃O
Molecular Weight:249.288
Hs Code.:

Synonyms:(S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine

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Chemical Property of (S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine

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Technology Process of (S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine

There total 6 articles about (S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310374-15-2
(S)-8-(2-fluoro-5-nitro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine

: 1310374-18-5
(S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine

Guidance literature:: With hydrogen; triethylamine; palladium 10% on activated carbon; In ethanol; at 22 ℃; for 1h; under 760.051 Torr;

Reference yield:

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1310374-18-5
(S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

2.2: 4 h

3.1: hydrogenchloride / ethyl acetate / 5.5 h / 65 °C / Sealed tube

4.1: borane-THF / tetrahydrofuran / 3 h / 0 °C

5.1: sodium acetate / tetrahydrofuran / 80 °C

5.2: 1 h / 22 °C

6.1: triethylamine; hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 22 °C / 760.05 Torr

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; borane-THF; hydrogen; sodium acetate; triethylamine; diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; ethyl acetate;

Reference yield:

: 1075231-42-3
{1-[(S)-1-amino-1-(2-fluoro-5-nitro-phenyl)-ethyl]-cyclopropyl}-methanol

: 1310374-18-5
(S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate / tetrahydrofuran / 80 °C

1.2: 1 h / 22 °C

2.1: triethylamine; hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 22 °C / 760.05 Torr

With hydrogen; sodium acetate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;