3-Aza-spiro[5.5]undecan-9-one hydrochloride

Base Information

• Chemical Name: 3-Aza-spiro[5.5]undecan-9-one hydrochloride
• CAS No.: 1225437-09-1
• Molecular Formula: C₁₀H₁₇NO*ClH
• Molecular Weight: 203.712
• Mol file: 1225437-09-1.mol

Synonyms:3-azaspiro[5.5]undecan-9-one hydrochloride

Chemical Property of 3-Aza-spiro[5.5]undecan-9-one hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-Azaspiro[5.5]undecan-9-one hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Aza-spiro[5.5]undecan-9-one hydrochloride

There total 10 articles about 3-Aza-spiro[5.5]undecan-9-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-oxo-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester (873924-08-4) → 3-azaspiro[5.5]undecan-9-one hydrochloride (1225437-09-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

3-tert-butyl 8-methyl 9-oxo-3-azaspiro[5.5]undecane-3,8-dicarboxylate (1225437-08-0) → 3-azaspiro[5.5]undecan-9-one hydrochloride (1225437-09-1)

Guidance literature:

With hydrogenchloride; water; at 0 ℃; Reflux;

Reference yield:

1-benzylpiperidine-4,4-diethanol (160133-33-5) → 3-azaspiro[5.5]undecan-9-one hydrochloride (1225437-09-1)

Guidance literature:

Multi-step reaction with 8 steps

1: hydrogen / palladium 10% on activated carbon / 2585.81 Torr

2: triethylamine / dichloromethane / 0.5 h / -20 °C

3: ethanol; water / 20 - 60 °C

4: hydrogenchloride; water / 0 °C / Reflux

5: thionyl chloride / 0 °C / Reflux

6: triethylamine / dichloromethane / 0 - 20 °C

7: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice

8: hydrogenchloride; water / 0 °C / Reflux

With hydrogenchloride; thionyl chloride; potassium tert-butylate; water; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;

upstream raw materials:

3-tert-butyl 8-methyl 9-oxo-3-azaspiro[5.5]undecane-3,8-dicarboxylate

1-t-Butoxycarbonylpiperidine-4,4-diethanol

1-benzylpiperidine-4,4-diethanol

tert-butyl 4,4-bis(2-cyanoethyl)piperidine-1-carboxylate

Downstream raw materials:

9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane

tert-Butyl 9-(azetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane-3-carboxylate

tert-Butyl 9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane-3-carboxylate

tert-Butyl 9-(3-fluorophenyl)-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecane-3-carboxylate

Refernces

• 1、 -. "Substituted Spiroamine Compounds". Page/Page column 38. . Retrieved 2010/05/13.