9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane

Base Information

Chemical Name:9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane
CAS No.:1225437-12-6
Molecular Formula:C₁₉H₂₆F₂N₂
Molecular Weight:320.426
Hs Code.:

Synonyms:9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane

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Chemical Property of 9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane

Chemical Property:

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Technology Process of 9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane

There total 18 articles about 9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1225437-11-5
tert-Butyl 9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane-3-carboxylate

: 1225437-12-6
9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 3h;

Reference yield:

: 160133-33-5
1-benzylpiperidine-4,4-diethanol

: 1225437-12-6
9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane

Guidance literature:: Multi-step reaction with 12 steps

1.1: hydrogen / palladium 10% on activated carbon / 2585.81 Torr

2.1: triethylamine / dichloromethane / 0.5 h / -20 °C

3.1: ethanol; water / 20 - 60 °C

4.1: hydrogenchloride; water / 0 °C / Reflux

5.1: thionyl chloride / 0 °C / Reflux

6.1: triethylamine / dichloromethane / 0 - 20 °C

7.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice

8.1: hydrogenchloride; water / 0 °C / Reflux

9.1: triethylamine / dichloromethane / 20 °C

10.1: acetic acid / methanol; water / 0 - 20 °C

10.2: Cooling with ice

11.1: tetrahydrofuran / 0 - 20 °C

12.1: trifluoroacetic acid / dichloromethane / 3 h

With hydrogenchloride; thionyl chloride; potassium tert-butylate; water; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

Reference yield:

: 2971-79-1
isonipecotic acid methyl ester

: 1225437-12-6
9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 12 h / 25 °C

2.1: lithium borohydride / tetrahydrofuran / 0 °C / Reflux

3.1: pyridinium chlorochromate / dichloromethane / 0 - 25 °C

4.1: potassium hydroxide / tetrahydrofuran; ethanol / 0 - 25 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 25 °C

6.1: acetic acid / methanol; water / 0 - 20 °C

6.2: Cooling with ice

7.1: tetrahydrofuran / 0 - 20 °C

8.1: trifluoroacetic acid / dichloromethane / 3 h

With lithium borohydride; hydrogen; acetic acid; triethylamine; pyridinium chlorochromate; trifluoroacetic acid; potassium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 3.1: Swern Oxidation;