5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine

Base Information

• Chemical Name: 5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine
• CAS No.: 116333-41-6
• Molecular Formula: C₁₇H₂₀N₆O₅
• Molecular Weight: 388.383
• Mol file: 116333-41-6.mol

Synonyms:5’-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3’-azido-3’-deoxythymidine

Chemical Property of 5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 143.64000
• Density: g/cm³
• LogP: 0.89066

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine

There total 6 articles about 5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-3'-deoxythymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) → 3'-azido-3'-deoxy-5'-O-<(1,4-dihydro-1-methyl-3-pyridyl)-carbonyl>thymidine (116333-41-6)

Guidance literature:

1: Acylation / 2: Alkylation / 3: Reduction;

DOI:10.1128/aac.41.1.122

Reference yield:

Nicotinic acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (116333-43-8) → 3'-azido-3'-deoxy-5'-O-<(1,4-dihydro-1-methyl-3-pyridyl)-carbonyl>thymidine (116333-41-6)

Guidance literature:

1: Alkylation / 2: Reduction;

DOI:10.1128/aac.41.1.122

Reference yield:

AZT-Q(1+) → 3'-azido-3'-deoxy-5'-O-<(1,4-dihydro-1-methyl-3-pyridyl)-carbonyl>thymidine (116333-41-6)

Guidance literature:

With sodium dithionite; sodium hydrogencarbonate; In water; ethyl acetate; for 2h; Yield given; Ambient temperature;

DOI:10.1021/jm00167a034

upstream raw materials:

carbon dioxide

nicotinic anhydride

3'-azido-2',3'-deoxythymidine

Nicotinic acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester