(4R,5S)-4-tert-butyldimethylsilyloxy-1-hydroxy-1,5-bis(4-methoxyphenyl)cyclohex-2-en-1-ol

Base Information

Chemical Name:(4R,5S)-4-tert-butyldimethylsilyloxy-1-hydroxy-1,5-bis(4-methoxyphenyl)cyclohex-2-en-1-ol
CAS No.:289503-62-4
Molecular Formula:C₂₆H₃₆O₄Si
Molecular Weight:440.655
Hs Code.:

Synonyms:(4R,5S)-4-tert-butyldimethylsilyloxy-1-hydroxy-1,5-bis(4-methoxyphenyl)cyclohex-2-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S)-4-tert-butyldimethylsilyloxy-1-hydroxy-1,5-bis(4-methoxyphenyl)cyclohex-2-en-1-ol

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Technology Process of (4R,5S)-4-tert-butyldimethylsilyloxy-1-hydroxy-1,5-bis(4-methoxyphenyl)cyclohex-2-en-1-ol

There total 6 articles about (4R,5S)-4-tert-butyldimethylsilyloxy-1-hydroxy-1,5-bis(4-methoxyphenyl)cyclohex-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 289503-61-3
(4R,5S)-4-tert-butyldimethylsilyloxy-5-(4-methoxyphenyl)cyclohex-2-en-1-one

: 289503-62-4
(4R,5S)-4-tert-butyldimethylsilyloxy-1-hydroxy-1,5-bis(4-methoxyphenyl)cyclohex-2-en-1-ol

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 3.5h;
DOI:10.3987/COM-00-8907

Reference yield:

: 121651-99-8
(4S,5R)-4,5-O-isopropylidenedioxycyclohex-2-en-1-one

: 289503-62-4
(4R,5S)-4-tert-butyldimethylsilyloxy-1-hydroxy-1,5-bis(4-methoxyphenyl)cyclohex-2-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: CuCN / diethyl ether / 0.5 h / -20 °C

2: 70 percent / imidazole / CH₂Cl₂ / 24 h / 20 °C

3: 66 percent / tetrahydrofuran / 3.5 h / 20 °C

With 1H-imidazole; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Grignard reaction / 2: Etherification / 3: Grignard reaction;
DOI:10.3987/COM-00-8907

Reference yield:

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 289503-62-4
(4R,5S)-4-tert-butyldimethylsilyloxy-1-hydroxy-1,5-bis(4-methoxyphenyl)cyclohex-2-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: CuCN / diethyl ether / 0.5 h / -20 °C

2: 70 percent / imidazole / CH₂Cl₂ / 24 h / 20 °C

3: 66 percent / tetrahydrofuran / 3.5 h / 20 °C

With 1H-imidazole; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Grignard reaction / 2: Etherification / 3: Grignard reaction;
DOI:10.3987/COM-00-8907