1,6,7,9-tetrahydro-1,9-dimethyl-6-<(phenylmethyl)imino>-8H-purin-8-one hydriodide

Base Information

• Chemical Name: 1,6,7,9-tetrahydro-1,9-dimethyl-6-<(phenylmethyl)imino>-8H-purin-8-one hydriodide
• CAS No.: 133329-69-8
• Molecular Formula: C₁₄H₁₅N₅O*HI
• Molecular Weight: 397.218
• Mol file: 133329-69-8.mol

Synonyms:1,6,7,9-tetrahydro-1,9-dimethyl-6-<(phenylmethyl)imino>-8H-purin-8-one hydriodide

Chemical Property of 1,6,7,9-tetrahydro-1,9-dimethyl-6-<(phenylmethyl)imino>-8H-purin-8-one hydriodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,6,7,9-tetrahydro-1,9-dimethyl-6-<(phenylmethyl)imino>-8H-purin-8-one hydriodide

There total 4 articles about 1,6,7,9-tetrahydro-1,9-dimethyl-6-<(phenylmethyl)imino>-8H-purin-8-one hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

7,9-dihydro-9-methyl-6-<(phenylmethyl)amino>-8H-purin-8-one (133329-67-6) + methyl iodide (74-88-4) → 1,6,7,9-tetrahydro-1,9-dimethyl-6-<(phenylmethyl)imino>-8H-purin-8-one hydriodide (133329-69-8) + 3,6,7,9-tetrahydro-3,9-dimethyl-6-<(phenylmethyl)imino>-8H-purin-8-one hydriodide

Guidance literature:

In N,N-dimethyl acetamide; at 38 - 42 ℃; for 94h;

DOI:10.1248/cpb.41.1746

Reference yield: 83.0%

7,9-dihydro-9-methyl-6-<(phenylmethyl)amino>-8H-purin-8-one (133329-67-6) + methyl iodide (74-88-4) → 1,6,7,9-tetrahydro-1,9-dimethyl-6-<(phenylmethyl)imino>-8H-purin-8-one hydriodide (133329-69-8) + 6-[(Z)-Benzylimino]-3,9-dimethyl-3,6,7,9-tetrahydro-purin-8-one; hydriodide (133329-68-7)

Guidance literature:

In N,N-dimethyl acetamide; at 46 ℃; for 79h;

DOI:10.1016/S0040-4039(00)71228-7

Reference yield:

1-Benzyl-6-imino-9-methyl-1,6,7,9-tetrahydro-purin-8-one (133329-66-5) → 1,6,7,9-tetrahydro-1,9-dimethyl-6-<(phenylmethyl)imino>-8H-purin-8-one hydriodide (133329-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / 1N aq. NaOH / 1 h / Heating

2: 7 percent / N,N-dimethyl-acetamide / 94 h / 38 - 42 °C

With sodium hydroxide; In N,N-dimethyl acetamide;

DOI:10.1248/cpb.41.1746

upstream raw materials:

7,9-dihydro-9-methyl-6-<(phenylmethyl)amino>-8H-purin-8-one

methyl iodide

1-Benzyl-6-imino-9-methyl-1,6,7,9-tetrahydro-purin-8-one

6-Amino-9-methyl-7H-purin-8(9H)-one

Downstream raw materials:

6-imino-1,9-dimethyl-8-oxopurine

1,6,7,9-tetrahydro-1,9-dimethyl-6-<(phenylmethyl)imino>-8H-purin-8-one hydrochloride