1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)oxy)phenyl)urea

Base Information

• Chemical Name: 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)oxy)phenyl)urea
• CAS No.: 1352798-70-9
• Molecular Formula: C₂₈H₂₇Cl₂N₇O₄
• Molecular Weight: 596.473
• Mol file: 1352798-70-9.mol

Synonyms:1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)oxy)phenyl)urea

Chemical Property of 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)oxy)phenyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)oxy)phenyl)urea

There total 9 articles about 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)oxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

7-(4-amino-2,3-dichlorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one (1352798-45-8) + 1,1'-carbonyldiimidazole (530-62-1) + 3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-amine (227623-26-9) → 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)oxy)phenyl)urea (1352798-70-9)

Guidance literature:

1,1'-carbonyldiimidazole; 3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-amine; In dichloromethane; at 20 ℃; for 18h;

7-(4-amino-2,3-dichlorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one; In tetrahydrofuran; dichloromethane; at 20 ℃; for 31h;

Reference yield:

4-hydroxy-2,3-dichloroaniline (39183-17-0) → 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)oxy)phenyl)urea (1352798-70-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 19 h / 20 °C

2.1: iron; acetic acid / 1.5 h / 55 °C

3.1: pyridine / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C

5.1: dichloromethane / 18 h / 20 °C

5.2: 31 h / 20 °C

With pyridine; iron; sodium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

C18H21N5O2 + 7-(4-amino-2,3-dichlorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one (1352798-45-8) → 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)oxy)phenyl)urea (1352798-70-9)

Guidance literature:

In tetrahydrofuran; dichloromethane; at 20 ℃; for 31h;

upstream raw materials:

4-hydroxy-2,3-dichloroaniline

4-chloro-3-nitro-2-pyridinamine

3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-amine

ethyl (2-amino-4-(4-amino-2,3-dichlorophenoxy)pyridin-3-yl)carbamate