4-Amino-2,3-dichlorophenol

Base Information

• Chemical Name: 4-Amino-2,3-dichlorophenol
• CAS No.: 39183-17-0
• Molecular Formula: C6H5 Cl2 N O
• Molecular Weight: 178.018
• Hs Code.: 2922299090
• European Community (EC) Number: 620-111-3,952-465-2
• DSSTox Substance ID: DTXSID90432174
• Wikidata: Q82246230
• Mol file: 39183-17-0.mol

Synonyms:4-amino-2,3-dichlorophenol;39183-17-0;4-Amino-2,3-dichlorphenol;4-hydroxy-2,3-dichloroaniline;PHENOL,4-AMINO-2,3-DICHLORO-;5,6-Dichlor-4-aminophenol;2,3-dichloro-4-hydroxyaniline;SCHEMBL1456970;DTXSID90432174;OQHWFUQNSLMSBG-UHFFFAOYSA-N;MFCD14455913;AKOS006333262;CS-W006732;DS-16759;A873700;AN-584/43422708

Chemical Property of 4-Amino-2,3-dichlorophenol

Chemical Property:

• Boiling Point: 301.9±42.0 °C(Predicted)
• PKA: 7.81±0.23(Predicted)
• PSA: 46.25000
• Density: 1.560±0.06 g/cm3(Predicted)
• LogP: 2.86240
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: DMSO, Methanol
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 176.9748192
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2,3-dichlorophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1N)Cl)Cl)O
• Uses: 4-Amino-2,3-dichlorophenol is used in the synthesis of Fenhexamid and other pyrazine compounds for use in drug formulations in treating inflammation, respiratory disorders and viral infections.

Technology Process of 4-Amino-2,3-dichlorophenol

There total 5 articles about 4-Amino-2,3-dichlorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,3-dichloro-4-(2-phenyldiazen-1-yl)phenol (201656-71-5) → 4-hydroxy-2,3-dichloroaniline (39183-17-0)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 4h; Reagent/catalyst; Cooling with ice;

Reference yield: 83.0%

2,2'-thiobis-ethanol (111-48-8) + 2,3-dichlorophenol (576-24-9) → 4-hydroxy-2,3-dichloroaniline (39183-17-0)

Guidance literature:

With hydrogenchloride; sodium hydroxide; hydrogen; aniline; sodium nitrite; aluminum nickel; In methanol; water;

Reference yield:

2,3-dichlorophenol (576-24-9) → 4-hydroxy-2,3-dichloroaniline (39183-17-0)

Guidance literature:

With hydrogenchloride; sodium hydroxide; hydrazine hydrate; aniline; sodium nitrite; aluminum nickel; In water; toluene;

upstream raw materials:

2,2'-thiobis-ethanol

2,3-dichlorophenol

1,2-Dichloro-3-nitrobenzene

2,3-dichloro-4-(2-phenyldiazen-1-yl)phenol

Downstream raw materials:

2,3-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)aniline

fenhexamid

1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((2-((3-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)phenyl)urea

1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((2-((3-(cyclopropylsulfonyl)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)phenyl)urea

Refernces

• 1、 -. "Preparation method of 2,3-dichloro-4-hydroxyaniline". Paragraph 0038; 0039; 0040. . Retrieved 2016/10/10.
• 2、 -. "Cycloalkylcarboxanilides". . . Retrieved 2008/06/13.