(1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

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Chemical Name:(1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide
CAS No.:473775-16-5
Molecular Formula:C₂₀H₃₁NO₄
Molecular Weight:349.47
Hs Code.:

Synonyms:(1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

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Chemical Property of (1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

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Technology Process of (1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

There total 1 articles about (1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 36255-44-4
3-bromopropanal dimethyl acetal

: 172016-00-1
(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide

: 473775-16-5
(1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: 3-bromopropanal dimethyl acetal; With iodine; magnesium; In tetrahydrofuran; at 20 ℃; for 2h;

(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide; In tetrahydrofuran; at -15 ℃; for 2.5h; Further stages.;
DOI:10.1039/b111540p

Reference yield: 49.0%

: 473775-16-5
(1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

: (1S,2R)-1-phenyl-2-[(R)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

: 473775-19-8
(1S,2R)-1-phenyl-2-[(S)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: (1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide; With carbon tetrabromide; triphenylphosphine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Further stages.;
DOI:10.1039/b111540p

Reference yield:

: 473775-16-5
(1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

: 473775-22-3
(1S,2R)-1-phenyl-2-[(S)-(pyrrolin-5-yl)methyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: PPh₃; CBr₄ / dimethylformamide / 0.5 h / 0 °C

1.2: 49 percent / NaN₃ / dimethylformamide / 3 h / 20 °C

2.1: 57 percent / aq. TFA / CH₂Cl₂ / 2 h / 20 °C

3.1: H₂ / 10percent Pd/C / methanol / 1 h / 20 °C / atmospheric pressure

3.2: 83 percent / 5 Angstroem molecular sieves / CH₂Cl₂ / 14 h / 20 °C

With carbon tetrabromide; hydrogen; triphenylphosphine; trifluoroacetic acid; 10percent Pd/C; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b111540p