(1S,2R)-1-phenyl-2-[(S)-(pyrrolin-5-yl)methyl]-N,N-diethylcyclopropanecarboxamide

Base Information

Chemical Name:(1S,2R)-1-phenyl-2-[(S)-(pyrrolin-5-yl)methyl]-N,N-diethylcyclopropanecarboxamide
CAS No.:473775-22-3
Molecular Formula:C₁₈H₂₄N₂O
Molecular Weight:284.401
Hs Code.:

Synonyms:(1S,2R)-1-phenyl-2-[(S)-(pyrrolin-5-yl)methyl]-N,N-diethylcyclopropanecarboxamide

Suppliers and Price of (1S,2R)-1-phenyl-2-[(S)-(pyrrolin-5-yl)methyl]-N,N-diethylcyclopropanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R)-1-phenyl-2-[(S)-(pyrrolin-5-yl)methyl]-N,N-diethylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R)-1-phenyl-2-[(S)-(pyrrolin-5-yl)methyl]-N,N-diethylcyclopropanecarboxamide

There total 4 articles about (1S,2R)-1-phenyl-2-[(S)-(pyrrolin-5-yl)methyl]-N,N-diethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 473775-21-2
(1S,2R)-1-phenyl-2-[(S)-1-azido-3-formylpropyl]-N,N-diethylcyclopropanecarboxamide

: 473775-22-3
(1S,2R)-1-phenyl-2-[(S)-(pyrrolin-5-yl)methyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: (1S,2R)-1-phenyl-2-[(S)-1-azido-3-formylpropyl]-N,N-diethylcyclopropanecarboxamide; With hydrogen; 10percent Pd/C; In methanol; at 20 ℃; for 1h; atmospheric pressure;

With 5A molecular sieve; In dichloromethane; at 20 ℃; for 14h; Further stages.;
DOI:10.1039/b111540p

Reference yield:

: 172016-00-1
(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide

: 473775-22-3
(1S,2R)-1-phenyl-2-[(S)-(pyrrolin-5-yl)methyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Mg; I₂ / tetrahydrofuran / 2 h / 20 °C

1.2: 91 percent / tetrahydrofuran / 2.5 h / -15 °C

2.1: PPh₃; CBr₄ / dimethylformamide / 0.5 h / 0 °C

2.2: 49 percent / NaN₃ / dimethylformamide / 3 h / 20 °C

3.1: 57 percent / aq. TFA / CH₂Cl₂ / 2 h / 20 °C

4.1: H₂ / 10percent Pd/C / methanol / 1 h / 20 °C / atmospheric pressure

4.2: 83 percent / 5 Angstroem molecular sieves / CH₂Cl₂ / 14 h / 20 °C

With carbon tetrabromide; hydrogen; iodine; magnesium; triphenylphosphine; trifluoroacetic acid; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1.2: Grignard reaction;
DOI:10.1039/b111540p

Reference yield:

: 473775-16-5
(1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

: 473775-22-3
(1S,2R)-1-phenyl-2-[(S)-(pyrrolin-5-yl)methyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: PPh₃; CBr₄ / dimethylformamide / 0.5 h / 0 °C

1.2: 49 percent / NaN₃ / dimethylformamide / 3 h / 20 °C

2.1: 57 percent / aq. TFA / CH₂Cl₂ / 2 h / 20 °C

3.1: H₂ / 10percent Pd/C / methanol / 1 h / 20 °C / atmospheric pressure

3.2: 83 percent / 5 Angstroem molecular sieves / CH₂Cl₂ / 14 h / 20 °C

With carbon tetrabromide; hydrogen; triphenylphosphine; trifluoroacetic acid; 10percent Pd/C; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b111540p