(1S,2R)-1-phenyl-2-[(S)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

Base Information

Chemical Name:(1S,2R)-1-phenyl-2-[(S)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide
CAS No.:473775-19-8
Molecular Formula:C₂₀H₃₀N₄O₃
Molecular Weight:374.483
Hs Code.:

Synonyms:(1S,2R)-1-phenyl-2-[(S)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

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Chemical Property of (1S,2R)-1-phenyl-2-[(S)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

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Technology Process of (1S,2R)-1-phenyl-2-[(S)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

There total 3 articles about (1S,2R)-1-phenyl-2-[(S)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 473775-16-5
(1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

: (1S,2R)-1-phenyl-2-[(R)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

: 473775-19-8
(1S,2R)-1-phenyl-2-[(S)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: (1S,2R)-1-phenyl-2-[(S)-1-hydroxy-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide; With carbon tetrabromide; triphenylphosphine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Further stages.;
DOI:10.1039/b111540p

Reference yield:

: 36255-44-4
3-bromopropanal dimethyl acetal

: 473775-19-8
(1S,2R)-1-phenyl-2-[(S)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg; I₂ / tetrahydrofuran / 2 h / 20 °C

1.2: 91 percent / tetrahydrofuran / 2.5 h / -15 °C

2.1: PPh₃; CBr₄ / dimethylformamide / 0.5 h / 0 °C

2.2: 49 percent / NaN₃ / dimethylformamide / 3 h / 20 °C

With carbon tetrabromide; iodine; magnesium; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.2: Grignard reaction;
DOI:10.1039/b111540p

Reference yield:

: 172016-00-1
(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide

: 473775-19-8
(1S,2R)-1-phenyl-2-[(S)-1-azido-4,4-dimethoxybutyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg; I₂ / tetrahydrofuran / 2 h / 20 °C

1.2: 91 percent / tetrahydrofuran / 2.5 h / -15 °C

2.1: PPh₃; CBr₄ / dimethylformamide / 0.5 h / 0 °C

2.2: 49 percent / NaN₃ / dimethylformamide / 3 h / 20 °C

With carbon tetrabromide; iodine; magnesium; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.2: Grignard reaction;
DOI:10.1039/b111540p