N-(2-nitrobenzoyl)tryptophan

Base Information

Chemical Name:N-(2-nitrobenzoyl)tryptophan
CAS No.:27261-93-4
Molecular Formula:C18H15 N3 O5
Molecular Weight:353.334
Hs Code.:

Synonyms:Tryptophan,N-(o-nitrobenzoyl)-, L- (8CI); NSC 382817

Suppliers and Price of N-(2-nitrobenzoyl)tryptophan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of N-(2-nitrobenzoyl)tryptophan

Chemical Property:

Vapor Pressure:2.24E-19mmHg at 25°C
Boiling Point:679.2°C at 760 mmHg
Flash Point:364.6°C
Density:1.455g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(2-nitrobenzoyl)tryptophan

There total 2 articles about N-(2-nitrobenzoyl)tryptophan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 610-14-0
2-nitrobenzyl chloride

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: 27261-93-4
(S)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 2h;
DOI:10.1002/cjoc.201400413

Reference yield:

: 552-16-9,104810-18-6
ortho-nitrobenzoic acid

: 27261-93-4
(S)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 3 h

2.1: sodium hydroxide / tetrahydrofuran / 2 h

2.2: pH 3

With thionyl chloride; sodium hydroxide; In tetrahydrofuran;
DOI:10.1039/c4ob00314d

Reference yield: 93.0%

: 2491-20-5
L-alanine methyl ester hydrochloride

: 27261-93-4
(S)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanoic acid

: 1602783-25-4
methyl (S)-{2-[(S)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanamido]propanoate}

Guidance literature:: (S)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanoic acid; With tert-butyl chloroformate; trimethyl orthoformate; In tetrahydrofuran; at -30 ℃; for 1h; Inert atmosphere;

L-alanine methyl ester hydrochloride; With 4-methyl-morpholine; In tetrahydrofuran; at -78 - -20 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c4ob00314d