[(7S,9S)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxy-8-oxa-1,4-dithia-spiro[4.5]dec-7-yl]-acetic acid tert-butyl ester

Base Information

Chemical Name:[(7S,9S)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxy-8-oxa-1,4-dithia-spiro[4.5]dec-7-yl]-acetic acid tert-butyl ester
CAS No.:104826-54-2
Molecular Formula:C₃₁H₄₄O₅S₂Si
Molecular Weight:588.905
Hs Code.:

Synonyms:[(7S,9S)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxy-8-oxa-1,4-dithia-spiro[4.5]dec-7-yl]-acetic acid tert-butyl ester

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Chemical Property of [(7S,9S)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxy-8-oxa-1,4-dithia-spiro[4.5]dec-7-yl]-acetic acid tert-butyl ester

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Technology Process of [(7S,9S)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxy-8-oxa-1,4-dithia-spiro[4.5]dec-7-yl]-acetic acid tert-butyl ester

There total 5 articles about [(7S,9S)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxy-8-oxa-1,4-dithia-spiro[4.5]dec-7-yl]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 67-56-1
methanol

: 96501-90-5
[(7S,9S)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-7-hydroxy-8-oxa-1,4-dithia-spiro[4.5]dec-7-yl]-acetic acid tert-butyl ester

: 104826-54-2
[(7S,9S)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxy-8-oxa-1,4-dithia-spiro[4.5]dec-7-yl]-acetic acid tert-butyl ester

Guidance literature:: With camphor-10-sulfonic acid; trimethyl orthoformate; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(00)98471-5

Reference yield:

: 96423-87-9
(S)-9-Hydroxymethyl-8-oxa-1,4-dithia-spiro[4.5]decan-7-one

: 104826-54-2
[(7S,9S)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxy-8-oxa-1,4-dithia-spiro[4.5]dec-7-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / Ambient temperature

2: 93 percent / LDA / tetrahydrofuran / -78 °C

3: 78 percent / CH(OMe)3/CSA / CH₂Cl₂ / Ambient temperature

With 1H-imidazole; camphor-10-sulfonic acid; lithium diisopropyl amide; trimethyl orthoformate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)98471-5

Reference yield:

: 4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-butyric acid tert-butyl ester

: 104826-54-2
[(7S,9S)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxy-8-oxa-1,4-dithia-spiro[4.5]dec-7-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: PCC/3A molecular sieves / CH₂Cl₂ / Ambient temperature

2: BF₃*Et₂O / CH₂Cl₂ / Ambient temperature

3: imidazole / dimethylformamide / Ambient temperature

4: 93 percent / LDA / tetrahydrofuran / -78 °C

5: 78 percent / CH(OMe)3/CSA / CH₂Cl₂ / Ambient temperature

With 1H-imidazole; 3 A molecular sieve; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; pyridinium chlorochromate; lithium diisopropyl amide; trimethyl orthoformate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)98471-5