N-(2-ethoxy-5-(3-(3-iodo-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(2-ethoxy-5-(3-(3-iodo-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide
CAS No.:1608146-53-7
Molecular Formula:C₂₀H₂₂IN₃O₅S
Molecular Weight:543.382
Hs Code.:

Synonyms:N-(2-ethoxy-5-(3-(3-iodo-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

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Chemical Property of N-(2-ethoxy-5-(3-(3-iodo-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

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Technology Process of N-(2-ethoxy-5-(3-(3-iodo-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

There total 7 articles about N-(2-ethoxy-5-(3-(3-iodo-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1608146-50-4
4-ethoxy-3-(methylsulfonamido)benzoic acid

: 1608146-89-9
3-chloro-N'-(3-iodo-4-isopropoxybenzoyl)-4-propoxybenzohydrazide

: 1608146-53-7
N-(2-ethoxy-5-(3-(3-iodo-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

Guidance literature:: 4-ethoxy-3-(methylsulfonamido)benzoic acid; 3-chloro-N'-(3-iodo-4-isopropoxybenzoyl)-4-propoxybenzohydrazide; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; at 40 ℃; for 2h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In dimethyl sulfoxide; at 120 ℃; for 1h; Inert atmosphere;

Reference yield:

: 59719-77-6
4-ethoxy-3-nitrobenzoic acid

: 1608146-53-7
N-(2-ethoxy-5-(3-(3-iodo-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 20 °C

2.1: sodium carbonate / water / 2 h / 0 - 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 2 h / 40 °C / Inert atmosphere

3.2: 1 h / 120 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; dimethyl sulfoxide;

Reference yield:

: 937625-32-6
ethyl 4-ethoxy-3-nitrobenzoate

: 1608146-53-7
N-(2-ethoxy-5-(3-(3-iodo-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; water / 1,4-dioxane / 1.2 h / Reflux

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 20 °C

3.1: sodium carbonate / water / 2 h / 0 - 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 2 h / 40 °C / Inert atmosphere

4.2: 1 h / 120 °C / Inert atmosphere

With palladium 10% on activated carbon; water; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide;