N-(2-ethoxy-5-(3-(3-iodo-4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(2-ethoxy-5-(3-(3-iodo-4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide
CAS No.:1608146-55-9
Molecular Formula:C₁₇H₁₆IN₃O₅S
Molecular Weight:501.302
Hs Code.:

Synonyms:N-(2-ethoxy-5-(3-(3-iodo-4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

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Chemical Property of N-(2-ethoxy-5-(3-(3-iodo-4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

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Technology Process of N-(2-ethoxy-5-(3-(3-iodo-4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

There total 9 articles about N-(2-ethoxy-5-(3-(3-iodo-4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1608146-53-7
N-(2-ethoxy-5-(3-(3-iodo-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

: 1608146-55-9
N-(2-ethoxy-5-(3-(3-iodo-4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

Guidance literature:: With boron trichloride; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 59719-77-6
4-ethoxy-3-nitrobenzoic acid

: 1608146-55-9
N-(2-ethoxy-5-(3-(3-iodo-4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 20 °C

2.1: sodium carbonate / water / 2 h / 0 - 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 2 h / 40 °C / Inert atmosphere

3.2: 1 h / 120 °C / Inert atmosphere

4.1: boron trichloride / dichloromethane / 1 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; boron trichloride; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1608146-50-4
4-ethoxy-3-(methylsulfonamido)benzoic acid

: 1608146-55-9
N-(2-ethoxy-5-(3-(3-iodo-4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 2 h / 40 °C / Inert atmosphere

1.2: 1 h / 120 °C / Inert atmosphere

2.1: boron trichloride / dichloromethane / 1 h / 0 - 20 °C

With boron trichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; dimethyl sulfoxide;