N-(5-(3-(2-(2-amino-1,3-dihydroxypropan-2-yl)benzofuran-5-yl)-1,2,4-oxadiazol-5-yl)-2-ethoxyphenyl)methanesulfonamide

Base Information

Chemical Name:N-(5-(3-(2-(2-amino-1,3-dihydroxypropan-2-yl)benzofuran-5-yl)-1,2,4-oxadiazol-5-yl)-2-ethoxyphenyl)methanesulfonamide
CAS No.:1608144-23-5
Molecular Formula:C₂₂H₂₄N₄O₇S
Molecular Weight:488.521
Hs Code.:

Synonyms:N-(5-(3-(2-(2-amino-1,3-dihydroxypropan-2-yl)benzofuran-5-yl)-1,2,4-oxadiazol-5-yl)-2-ethoxyphenyl)methanesulfonamide

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Chemical Property of N-(5-(3-(2-(2-amino-1,3-dihydroxypropan-2-yl)benzofuran-5-yl)-1,2,4-oxadiazol-5-yl)-2-ethoxyphenyl)methanesulfonamide

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Technology Process of N-(5-(3-(2-(2-amino-1,3-dihydroxypropan-2-yl)benzofuran-5-yl)-1,2,4-oxadiazol-5-yl)-2-ethoxyphenyl)methanesulfonamide

There total 11 articles about N-(5-(3-(2-(2-amino-1,3-dihydroxypropan-2-yl)benzofuran-5-yl)-1,2,4-oxadiazol-5-yl)-2-ethoxyphenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1608146-57-1
tert-butyl N-(5-{5-[5-(4-ethoxy-3-methanesulfonamidophenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate

: 1608144-23-5
N-(5-(3-(2-(2-amino-1,3-dihydroxypropan-2-yl)benzofuran-5-yl)-1,2,4-oxadiazol-5-yl)-2-ethoxyphenyl)methanesulfonamide

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 59719-77-6
4-ethoxy-3-nitrobenzoic acid

: 1608144-23-5
N-(5-(3-(2-(2-amino-1,3-dihydroxypropan-2-yl)benzofuran-5-yl)-1,2,4-oxadiazol-5-yl)-2-ethoxyphenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 20 °C

2.1: sodium carbonate / water / 2 h / 0 - 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 2 h / 40 °C / Inert atmosphere

3.2: 1 h / 120 °C / Inert atmosphere

4.1: boron trichloride / dichloromethane / 1 h / 0 - 20 °C

5.1: copper(I) oxide; pyridine / 5 h / 110 °C / Inert atmosphere

6.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 1 h / 20 °C / Inert atmosphere

With pyridine; copper(I) oxide; chloro-trimethyl-silane; palladium 10% on activated carbon; hydrogen; boron trichloride; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; In ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1608146-55-9
N-(2-ethoxy-5-(3-(3-iodo-4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanesulfonamide

: 1608144-23-5
N-(5-(3-(2-(2-amino-1,3-dihydroxypropan-2-yl)benzofuran-5-yl)-1,2,4-oxadiazol-5-yl)-2-ethoxyphenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(I) oxide; pyridine / 5 h / 110 °C / Inert atmosphere

2: sodium iodide; chloro-trimethyl-silane / acetonitrile / 1 h / 20 °C / Inert atmosphere

With pyridine; copper(I) oxide; chloro-trimethyl-silane; sodium iodide; In acetonitrile;