1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

Base Information

Chemical Name:1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate
CAS No.:1240518-60-8
Molecular Formula:C₂₉H₂₆Cl₂F₂N₄O₆S₄
Molecular Weight:763.715
Hs Code.:

Synonyms:1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

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Chemical Property of 1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

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Technology Process of 1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

There total 10 articles about 1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1240518-59-5
1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-formyl-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate

: 1240518-60-8
1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1240518-60-8
1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 60 °C

3: diisobutylaluminium hydride / toluene / 3.75 h / -10 - 0 °C

4: diethylamino-sulfur trifluoride / dichloromethane / 5 h

With sodium tetrahydroborate; diethylamino-sulfur trifluoride; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; toluene; 2: |Mitsunobu Displacement;
DOI:10.1021/jm301572h

Reference yield:

: 65610-13-1
3-fluoro-1,2-benzenedicarbonitrile

: 1240518-60-8
1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(difluoromethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrazine hydrate / ethanol / 70 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane; acetonitrile / 0.5 h / Inert atmosphere

3: dichloromethane / 62 h / 45 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1.17 h

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 60 °C

6: diisobutylaluminium hydride / toluene / 3.75 h / -10 - 0 °C

7: diethylamino-sulfur trifluoride / dichloromethane / 5 h

With dmap; diethylamino-sulfur trifluoride; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; hydrazine hydrate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile; 5: |Mitsunobu Displacement;
DOI:10.1021/jm301572h