1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-formyl-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-formyl-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate
CAS No.:1240518-59-5
Molecular Formula:C₂₉H₂₆Cl₂N₄O₇S₄
Molecular Weight:741.718
Hs Code.:

Synonyms:1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-formyl-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate

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Chemical Property of 1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-formyl-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate

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Technology Process of 1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-formyl-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate

There total 9 articles about 1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-formyl-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1240518-58-4
1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate

: 1240518-59-5
1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-formyl-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate

Guidance literature:: 1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1Hindazol-1-yl)methyl]phenyl}methyl)carbamate; With diisobutylaluminium hydride; In toluene; at -10 - 0 ℃;

With methanol; In toluene;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1240518-59-5
1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-formyl-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 60 °C

3: diisobutylaluminium hydride / toluene / 3.75 h / -10 - 0 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; nickel dichloride; In tetrahydrofuran; methanol; toluene; 2: |Mitsunobu Displacement;
DOI:10.1021/jm301572h

Reference yield:

: 874-97-5
3-(hydroxymethyl)benzonitrile

: 1240518-59-5
1,1-dimethylethyl ({3-[(3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-formyl-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 60 °C

3: diisobutylaluminium hydride / toluene / 3.75 h / -10 - 0 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; nickel dichloride; In tetrahydrofuran; methanol; toluene; 2: |Mitsunobu Displacement;
DOI:10.1021/jm301572h