2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

Base Information

Chemical Name:2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide
CAS No.:159780-12-8
Molecular Formula:C₁₆H₁₇F₃N₂O₄
Molecular Weight:358.317
Hs Code.:

Synonyms:2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

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Chemical Property of 2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

Chemical Property:

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Technology Process of 2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

There total 1 articles about 2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60-35-5
acetamide

: 159780-12-8
2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

Guidance literature:

Reference yield:

: 159780-12-8
2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

: 2-[3-(1,1-Dimethyl-2-phenyl-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1: 2,6-lutidine / tetrahydrofuran / 16 h / Ambient temperature

2: 81 percent / N₂H₄*H₂O / 3 h / Heating

3: 48 percent / 24 h / 120 °C / 1 Torr

4: 96 percent / LiI / pyridine / 14 h / Heating

5: 84 percent / diphenyl phosphoroazidate, TEA / dioxane / 4 h / Heating

6: 53 percent / aq. LiOH*H₂O / ethanol / 7 h / 0 °C

7: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature

8: dimethylformamide / 2.5 h / 120 °C

9: TBAF / tetrahydrofuran / 2 h / Ambient temperature

10: EDAC, 2,2-dichloroacetic acid / dimethylsulfoxide; toluene / 16 h / Ambient temperature

With 2,6-dimethylpyridine; dichloro-acetic acid; lithium hydroxide; TEA; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm950684z

Reference yield:

: 159780-12-8
2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

: 159780-40-2
N-(3,3,3-Trifluoro-2-hydroxy-1-isopropyl-propyl)-2-(2,4,8-trioxo-3-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl)-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: 2,6-lutidine / tetrahydrofuran / 16 h / Ambient temperature

2: 81 percent / N₂H₄*H₂O / 3 h / Heating

3: 71 percent / ethanol / 16 h / Heating

4: LiI / pyridine / 14 h / Heating

5: diphenyl phosphorazidate, TEA / dioxane / 4 h / Heating

6: aq. LiOH*H₂O / ethanol / 7 h / 0 °C

7: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature

8: dimethylformamide / 2.5 h / 120 °C

9: TBAF / tetrahydrofuran / 2 h / Ambient temperature

With 2,6-dimethylpyridine; lithium hydroxide; TEA; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950684z