4-[8-(4-Methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-[1,3]dioxolane-2-thione

Base Information

Chemical Name:4-[8-(4-Methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-[1,3]dioxolane-2-thione
CAS No.:151251-81-9
Molecular Formula:C₁₈H₂₂O₅S
Molecular Weight:350.436
Hs Code.:

Synonyms:4-[8-(4-Methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-[1,3]dioxolane-2-thione

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Chemical Property of 4-[8-(4-Methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-[1,3]dioxolane-2-thione

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Technology Process of 4-[8-(4-Methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-[1,3]dioxolane-2-thione

There total 7 articles about 4-[8-(4-Methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-[1,3]dioxolane-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 463-71-8
thiophosgene

: Acetic acid 2-hydroxy-2-[8-(4-methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-ethyl ester

: 151251-81-9
4-[8-(4-Methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-[1,3]dioxolane-2-thione

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)73621-5

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 151251-81-9
4-[8-(4-Methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-[1,3]dioxolane-2-thione

Guidance literature:: Multi-step reaction with 7 steps

1: NaH / 1,2-dimethoxy-ethane

2: LAH / diethyl ether

3: pyridine

4: benzene / 0 °C / Irradiation

5: 70 percent / Zn / pyridine / Heating

6: K₂CO₃ / acetone

7: 77 percent / Et₃N / CH₂Cl₂

With pyridine; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; triethylamine; zinc; In pyridine; 1,2-dimethoxyethane; diethyl ether; dichloromethane; acetone; benzene;
DOI:10.1016/S0040-4039(00)73621-5

Reference yield:

: 51656-91-8
ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate

: 151251-81-9
4-[8-(4-Methoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-[1,3]dioxolane-2-thione

Guidance literature:: Multi-step reaction with 6 steps

1: LAH / diethyl ether

2: pyridine

3: benzene / 0 °C / Irradiation

4: 70 percent / Zn / pyridine / Heating

5: K₂CO₃ / acetone

6: 77 percent / Et₃N / CH₂Cl₂

With pyridine; lithium aluminium tetrahydride; potassium carbonate; triethylamine; zinc; In pyridine; diethyl ether; dichloromethane; acetone; benzene;
DOI:10.1016/S0040-4039(00)73621-5