N-hydroxy-3-phenyl-propynimidic acid amide

Base Information

• Chemical Name: N-hydroxy-3-phenyl-propynimidic acid amide
• CAS No.: 10284-97-6
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.175
• Mol file: 10284-97-6.mol

Synonyms:N-hydroxy-3-phenyl-propynimidic acid amide

Chemical Property of N-hydroxy-3-phenyl-propynimidic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-hydroxy-3-phenyl-propynimidic acid amide

There total 4 articles about N-hydroxy-3-phenyl-propynimidic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Phenyl-2-propynonitrile (935-02-4) → N-hydroxy-3-phenyl-propynimidic acid amide (10284-97-6)

Guidance literature:

With hydroxylamine; In ethanol; water; for 3h; Reflux;

DOI:10.1039/c9ob01547g

Reference yield:

Phenylpropargyl aldehyde (2579-22-8) → N-hydroxy-3-phenyl-propynimidic acid amide (10284-97-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine / acetonitrile / 2 h / Reflux

2: triethylamine; fluorosulfonyl fluoride / acetonitrile / 0.5 h / 20 °C

3: hydroxylamine / acetonitrile / 3 h / Reflux

With fluorosulfonyl fluoride; hydroxylamine; triethylamine; In acetonitrile;

DOI:10.1039/d0ra02631j

Reference yield:

3-phenylpropynal oxime (858445-43-9) → N-hydroxy-3-phenyl-propynimidic acid amide (10284-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; fluorosulfonyl fluoride / acetonitrile / 0.5 h / 20 °C

2: hydroxylamine / acetonitrile / 3 h / Reflux

With fluorosulfonyl fluoride; hydroxylamine; triethylamine; In acetonitrile;

DOI:10.1039/d0ra02631j

upstream raw materials:

3-Phenyl-2-propynonitrile

Phenylpropargyl aldehyde

3-phenylpropynal oxime

Downstream raw materials:

3-phenylethynyl-[1,2,4]oxadiazole

4-[1,2,4]oxadiazol-3-ylethynyl-aniline

3-(2-nitro-phenylethynyl)-[1,2,4]oxadiazole

3-(4-nitro-phenylethynyl)-[1,2,4]oxadiazole