858445-43-9

Basic information

• Product Name: 3-phenylpropynal oxime
• Synonyms: 3-phenylpropynal oxime
• CAS NO: 858445-43-9
• Molecular Weight: 145.161
• Mol File: 858445-43-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-phenylpropynal oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylpropynal oxime(858445-43-9)
• EPA Substance Registry System: 3-phenylpropynal oxime(858445-43-9)

Safety Data

• Hazardous Substances Data: 858445-43-9(Hazardous Substances Data)

Upstream product

• 2579-22-8 Phenylpropargyl aldehyde 
• 24247-46-9 α-bromo-cis-cinnamaldehyde seqtrans-oxime 

Downstream Products

• 614-16-4 Benzoylacetonitrile 
• 1006-67-3 5-phenylisoxazole 
• 935-02-4 3-Phenyl-2-propynonitrile 
• 10284-97-6 N-hydroxy-3-phenyl-propynimidic acid amide 
• 1354930-11-2 3-phenylethynyl-8-(6-methyl-3-nitro-2-pyridyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene 
• 1354931-49-9 3-phenylethynyl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene 
• 1354931-48-8 tert-butyl 3-(phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-8-carboxylate 

Relevant articles and documents

SO 2 F 2 -Promoted Dehydration of Aldoximes: A Rapid and Simple Access to Nitriles

A rapid, simple and mild process for the dehydration of aldoximes to give the corresponding nitriles, which utilizes SO 2 F 2 as an efficient reagent, has been developed. A variety of (hetero)arene, alkene, alkyne and aliphatic aldoximes proceeded with high efficiency to afford nitriles in excellent to quantitative yields with great functional group compatibilities in acetonitrile under ambient conditions. Furthermore, an eco-friendly synthetic protocol to access nitriles from aldehydes with ortho -, meta - and para -nitrile groups was also described in aqueous methanol by using inorganic base Na 2 CO 3, and a one-pot synthetic strategy to generate nitriles from aldehydes was proved to be feasible.

Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO

A simple, mild, and practical process for direct conversion of aldehydes to nitriles was developed feathering a wide substrate scope and great functional group tolerability (52 examples, over 90% yield in most cases) using inorganic reagents (NH2OH/Na2CO3/SO2F2) in DMSO. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable nitriles in a pot, atom, and step-economical manner without transition metals. This protocol will serve as a robust tool for the installation of cyano-moieties to complicated molecules.

A practical and cost-efficient, one-pot conversion of aldehydes into nitriles mediated by 'activated DMSO'

Participation of activated DMSO in the one-pot transformation of aldehydes to nitriles has been described by reacting aldehydes with NHHHCl in DMSO in the absence of any added base or catalyst. The method is applicable to access a wide range of aromatic, heterocyclic, and aliphatic nitriles, in which only water is a byproduct. A straightforward and practical procedure is demonstrated on a multigram scale. Georg Thieme Verlag Stuttgart - New York.