4-(2,6-dimethylphenyl)-3-(4-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole

Base Information

Chemical Name:4-(2,6-dimethylphenyl)-3-(4-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole
CAS No.:1297270-45-1
Molecular Formula:C₁₉H₂₀FN₃
Molecular Weight:309.386
Hs Code.:

Synonyms:4-(2,6-dimethylphenyl)-3-(4-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2,6-dimethylphenyl)-3-(4-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole

Chemical Property:

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Technology Process of 4-(2,6-dimethylphenyl)-3-(4-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole

There total 6 articles about 4-(2,6-dimethylphenyl)-3-(4-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

hydrazine monohydrate (NH₂NH_2.H₂O): hydrazine monohydrate (NH₂NH_2.H₂O)

: N-[(ethylsulfanyl)(4-fluorophenyl)methylidene]-2,6-dimethylaniline

: 97-62-1
Ethyl isobutyrate

: 71-36-3
butan-1-ol

: 1297270-45-1
4-(2,6-dimethylphenyl)-3-(4-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole

Guidance literature:

Reference yield:

: 1297270-38-2
N-[(ethylsulfanyl)(4-fluorophenyl)methylidene]-2,6-dimethylaniline

: 3619-17-8
isobutyric acid hydrazide

: 1297270-45-1
4-(2,6-dimethylphenyl)-3-(4-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole

Guidance literature:: In butan-1-ol; at 130 ℃; for 22h;

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 1297270-45-1
4-(2,6-dimethylphenyl)-3-(4-fluorophenyl)-5-isopropyl-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

2.1: Lawessons reagent / toluene / 3 h / 130 °C

3.1: sodium ethanolate / ethanol / 1 h / 20 °C

3.2: 5 h / 60 °C

4.1: butan-1-ol / 22 h / 130 °C

With Lawessons reagent; sodium ethanolate; triethylamine; In tetrahydrofuran; ethanol; toluene; butan-1-ol;