3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine

Base Information

Chemical Name:3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine
CAS No.:1232359-36-2
Molecular Formula:C₂₇H₄₀N₂O₇Si
Molecular Weight:532.709
Hs Code.:

Synonyms:3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine

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Technology Process of 3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine

There total 2 articles about 3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1232359-33-9
3'-O-benzyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1232359-36-2
3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine

Guidance literature:: With 1H-imidazole; In acetonitrile;
DOI:10.1134/S1068162010020093

Reference yield:

: 1204744-83-1
2'-O-acetyl-3'-O-benzyl-5'-deoxy-5'-ethoxycarbonylmethyl-5-methyluridine

: 1232359-36-2
3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; potassium carbonate / 4 h

1.2: 0.08 h

2.1: 1H-imidazole / acetonitrile

With 1H-imidazole; methanol; potassium carbonate; In acetonitrile;
DOI:10.1134/S1068162010020093

Reference yield: 93.0%

: 1232359-36-2
3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine

: 1232359-39-5
3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-carboxymethylribosylthymine

Guidance literature:: 3'-O-benzyl-2'-O-tert-butyldimethylsilyl-5'-deoxy-5'-ethoxycarbonylmethylribosylthymine; With potassium hydroxide; In ethanol; for 1h;

With potassium hydrogensulfate; In ethanol; water;
DOI:10.1134/S1068162010020093