tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl]carbonyl}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl]carbonyl}piperidine-1-carboxylate
CAS No.:1241898-34-9
Molecular Formula:C₂₀H₂₈FNO₃
Molecular Weight:349.446
Hs Code.:

Synonyms:tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl]carbonyl}piperidine-1-carboxylate

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Chemical Property of tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl]carbonyl}piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl]carbonyl}piperidine-1-carboxylate

There total 3 articles about tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl]carbonyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241898-35-0
tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl](hydroxy)methyl}piperidine-1-carboxylate

: 1241898-34-9
tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl]carbonyl}piperidine-1-carboxylate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 7073-69-0
2-(2-bromophenyl)propanol

: 1241898-34-9
tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl]carbonyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / -78 °C

2.1: tert.-butyl lithium / ethyl acetate; pentane; tetrahydrofuran / -78 °C

2.2: 1.75 h / -78 - 20 °C

3.1: Dess-Martin periodane / dichloromethane / 16 h / 20 °C

With diethylamino-sulfur trifluoride; tert.-butyl lithium; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; ethyl acetate; pentane;

Reference yield:

: 1027513-78-5
1-bromo-2-(2-fluoropropan-2-yl)benzene

: 1241898-34-9
tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl]carbonyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / ethyl acetate; pentane; tetrahydrofuran / -78 °C

1.2: 1.75 h / -78 - 20 °C

2.1: Dess-Martin periodane / dichloromethane / 16 h / 20 °C

With tert.-butyl lithium; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; ethyl acetate; pentane;