tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl](hydroxy)methyl}piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl](hydroxy)methyl}piperidine-1-carboxylate
• CAS No.: 1241898-35-0
• Molecular Formula: C₂₀H₃₀FNO₃
• Molecular Weight: 351.462
• Mol file: 1241898-35-0.mol

Synonyms:tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl](hydroxy)methyl}piperidine-1-carboxylate

Chemical Property of tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl](hydroxy)methyl}piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl](hydroxy)methyl}piperidine-1-carboxylate

There total 2 articles about tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl](hydroxy)methyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-2-(2-fluoropropan-2-yl)benzene (1027513-78-5) + tert butyl 4-formylpiperidine-1-carboxylate (137076-22-3) → tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl](hydroxy)methyl}piperidine-1-carboxylate (1241898-35-0)

Guidance literature:

1-bromo-2-(2-fluoropropan-2-yl)benzene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃;

tert butyl 4-formylpiperidine-1-carboxylate; In tetrahydrofuran; pentane; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; pentane;

Reference yield:

2-(2-bromophenyl)propanol (7073-69-0) → tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl](hydroxy)methyl}piperidine-1-carboxylate (1241898-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / -78 °C

2.1: tert.-butyl lithium / ethyl acetate; pentane; tetrahydrofuran / -78 °C

2.2: 1.75 h / -78 - 20 °C

With diethylamino-sulfur trifluoride; tert.-butyl lithium; In tetrahydrofuran; dichloromethane; ethyl acetate; pentane;

Reference yield:

tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl](hydroxy)methyl}piperidine-1-carboxylate (1241898-35-0) → tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl]carbonyl}piperidine-1-carboxylate (1241898-34-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

1-bromo-2-(2-fluoropropan-2-yl)benzene

tert butyl 4-formylpiperidine-1-carboxylate

2-(2-bromophenyl)propanol

Downstream raw materials:

tert-butyl-4-{[2-(2-fluoropropan-2-yl)phenyl]carbonyl}piperidine-1-carboxylate