2-acetylamino-3-methylpentanoic acid (5-benzyl-14,17-di-sec-butyl-4,7,13,16,19-pentaoxo-eicosahydro-3a,6,12,15,18-pentaaza-cyclopentacyclooctadecen-8-yl)amide

Base Information

Chemical Name:2-acetylamino-3-methylpentanoic acid (5-benzyl-14,17-di-sec-butyl-4,7,13,16,19-pentaoxo-eicosahydro-3a,6,12,15,18-pentaaza-cyclopentacyclooctadecen-8-yl)amide
CAS No.:1233083-92-5
Molecular Formula:C₃₉H₆₁N₇O₇
Molecular Weight:739.956
Hs Code.:

2-acetylamino-3-methylpentanoic acid (5-benzyl-14,17-di-sec-butyl-4,7,13,16,19-pentaoxo-eicosahydro-3a,6,12,15,18-pentaaza-cyclopentacyclooctadecen-8-yl)amide

Synonyms:2-acetylamino-3-methylpentanoic acid (5-benzyl-14,17-di-sec-butyl-4,7,13,16,19-pentaoxo-eicosahydro-3a,6,12,15,18-pentaaza-cyclopentacyclooctadecen-8-yl)amide

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Chemical Property of 2-acetylamino-3-methylpentanoic acid (5-benzyl-14,17-di-sec-butyl-4,7,13,16,19-pentaoxo-eicosahydro-3a,6,12,15,18-pentaaza-cyclopentacyclooctadecen-8-yl)amide

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Technology Process of 2-acetylamino-3-methylpentanoic acid (5-benzyl-14,17-di-sec-butyl-4,7,13,16,19-pentaoxo-eicosahydro-3a,6,12,15,18-pentaaza-cyclopentacyclooctadecen-8-yl)amide

There total 4 articles about 2-acetylamino-3-methylpentanoic acid (5-benzyl-14,17-di-sec-butyl-4,7,13,16,19-pentaoxo-eicosahydro-3a,6,12,15,18-pentaaza-cyclopentacyclooctadecen-8-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 5854-47-7,19764-31-9,20257-17-4,33601-90-0,54831-20-8,73465-39-1,3077-46-1
(2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid

: C₃₁H₄₈N₆O₅

: 1233083-92-5
2-acetylamino-3-methylpentanoic acid (5-benzyl-14,17-di-sec-butyl-4,7,13,16,19-pentaoxo-eicosahydro-3a,6,12,15,18-pentaaza-cyclopentacyclooctadecen-8-yl)amide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 6-chloro-1-hydroxybenzotriazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2018.10.025

Reference yield:

: 7733-29-1,199924-46-4
Z-Orn(Boc)-OH

: 1233083-92-5
2-acetylamino-3-methylpentanoic acid (5-benzyl-14,17-di-sec-butyl-4,7,13,16,19-pentaoxo-eicosahydro-3a,6,12,15,18-pentaaza-cyclopentacyclooctadecen-8-yl)amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 6-chloro-1-hydroxybenzotriazole / N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 3 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 48 h / 20 °C

3.1: 6-chloro-1-hydroxybenzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 6-chloro-1-hydroxybenzotriazole; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2018.10.025

Reference yield:

: C₃₉H₅₄N₆O₇

: 1233083-92-5
2-acetylamino-3-methylpentanoic acid (5-benzyl-14,17-di-sec-butyl-4,7,13,16,19-pentaoxo-eicosahydro-3a,6,12,15,18-pentaaza-cyclopentacyclooctadecen-8-yl)amide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 48 h / 20 °C

2: 6-chloro-1-hydroxybenzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 6-chloro-1-hydroxybenzotriazole; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2018.10.025