1-(Diphenylmethyl)-4-[(2,4,6-trimethylphenyl)sulfonyl]piperazine

Base Information

• Chemical Name: 1-(Diphenylmethyl)-4-[(2,4,6-trimethylphenyl)sulfonyl]piperazine
• CAS No.: 5854-47-7
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 173.212
• DSSTox Substance ID: DTXSID70361291
• Wikidata: Q82143562

Synonyms:313402-61-8;1-(diphenylmethyl)-4-[(2,4,6-trimethylphenyl)sulfonyl]piperazine;1-(diphenylmethyl)-4-(2,4,6-trimethylbenzenesulfonyl)piperazine;5854-47-7;Oprea1_580667;Oprea1_641036;DTXSID70361291;STK354835;AKOS002286450;1-benzhydryl-4-(mesitylsulfonyl)piperazine;Z44546314;F0284-0073;1-(Diphenylmethyl)-4-(2,4,6-trimethylbenzene-1-sulfonyl)piperazine

Chemical Property of 1-(Diphenylmethyl)-4-[(2,4,6-trimethylphenyl)sulfonyl]piperazine

Chemical Property:

• Vapor Pressure: 1.24E-12mmHg at 25°C
• Boiling Point: 561.4°C at 760 mmHg
• Flash Point: 293.3°C
• Density: 1.184g/cm³
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 434.20279938
• Heavy Atom Count: 31
• Complexity: 625

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)C)S(=O)(=O)N2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C

Technology Process of 1-(Diphenylmethyl)-4-[(2,4,6-trimethylphenyl)sulfonyl]piperazine

There total 28 articles about 1-(Diphenylmethyl)-4-[(2,4,6-trimethylphenyl)sulfonyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

L-isoleucine (73-32-5,959215-79-3,18875-42-8) + acetic anhydride (108-24-7) → (2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid (5854-47-7,19764-31-9,20257-17-4,33601-90-0,54831-20-8,73465-39-1,3077-46-1)

Guidance literature:

In methanol; Reflux;

DOI:10.1002/anie.201611852

Reference yield: 87.0%

L-isoleucine (73-32-5,959215-79-3,18875-42-8) + acetyl chloride (75-36-5) → (2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid (5854-47-7,19764-31-9,20257-17-4,33601-90-0,54831-20-8,73465-39-1,3077-46-1)

Guidance literature:

In water; at 110 ℃; for 0.0833333h; chemoselective reaction; Microwave irradiation; Green chemistry;

DOI:10.1039/c4ra16683c

Reference yield: 72.0%

N-Ac-Ile-OMe → (2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid (5854-47-7,19764-31-9,20257-17-4,33601-90-0,54831-20-8,73465-39-1,3077-46-1)

Guidance literature:

With sodium hydroxide; phosphate buffer; pronase EC 3.4.24.4; In tetrahydrofuran; Ambient temperature;

upstream raw materials:

L-isoleucine

acetic anhydride

acetic acid

D-alloisoleucine

Downstream raw materials:

N-Acetyl-DL-isoleucin-ethylester

Ac-ISVU(Ph)RSTS

N-acetyl-L-isoleucyl-O-benzyl-L-tyrosine methyl ester

L-isoleucine

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