1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol

Base Information

Chemical Name:1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol
CAS No.:117023-80-0
Molecular Formula:C₂₇H₃₀F₂N₂O₂
Molecular Weight:452.544
Hs Code.:

Synonyms:1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol

Chemical Property:

Purity/Quality:

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Technology Process of 1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol

There total 7 articles about 1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 111626-61-0
α,α-bis(4-fluorophenyl)-1-[3-(4-nitrophenoxy)propyl]-4-piperidinemethanol

: 117023-80-0
1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 4h; under 2068.6 Torr; Ambient temperature;
DOI:10.1021/jm00121a022

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 117023-80-0
1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / K₂CO₃ / acetone / 24 h / Heating

2: 73 percent / Na₂CO₃, KI / butan-1-ol / Heating

3: 62 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 4 h / 2068.6 Torr / Ambient temperature

With hydrogen; sodium carbonate; potassium carbonate; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; acetone; butan-1-ol;
DOI:10.1021/jm00121a022

Reference yield:

: 79096-54-1
1-(3-Chloropropoxy)-4-nitrobenzene

: 117023-80-0
1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / Na₂CO₃, KI / butan-1-ol / Heating

2: 62 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 4 h / 2068.6 Torr / Ambient temperature

With hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; butan-1-ol;
DOI:10.1021/jm00121a022