(2S,3S)-4-benzyloxy-2-hydroxy-3-methylbuttersaeure

Base Information

Chemical Name:(2S,3S)-4-benzyloxy-2-hydroxy-3-methylbuttersaeure
CAS No.:111833-00-2
Molecular Formula:C₁₂H₁₆O₄
Molecular Weight:224.257
Hs Code.:

Synonyms:(2S,3S)-4-benzyloxy-2-hydroxy-3-methylbuttersaeure

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-4-benzyloxy-2-hydroxy-3-methylbuttersaeure

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Technology Process of (2S,3S)-4-benzyloxy-2-hydroxy-3-methylbuttersaeure

There total 5 articles about (2S,3S)-4-benzyloxy-2-hydroxy-3-methylbuttersaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 111833-04-6
(2S,3S)-2-Acetoxy-4-benzyloxy-3-methyl-butyric acid methyl ester

: 111833-00-2
(2S,3S)-4-benzyloxy-2-hydroxy-3-methylbuttersaeure

Guidance literature:: With potassium hydroxide; In methanol; water; Ambient temperature;
DOI:10.1002/hlca.19870700204

Reference yield:

: 73840-71-8
diethyl (2S,3R)-(+)-2-hydroxy-3-methylsuccinate

: 111833-00-2
(2S,3S)-4-benzyloxy-2-hydroxy-3-methylbuttersaeure

Guidance literature:: Multi-step reaction with 6 steps

1: KOH / methanol; H₂O / 24 h / Ambient temperature

2: 1.) 1 h, r.t; 2.) 2 h, 60 deg C

3: 1.) 10 min, r.t; 2.) 1 h, 60 deg C

4: 85 percent / BH₃ / tetrahydrofuran / Ambient temperature

5: trifluoromethanesulfonic acid / cyclohexane; CH₂Cl₂ / 12 h / Ambient temperature

6: 74 percent / KOH / methanol; H₂O / Ambient temperature

With potassium hydroxide; trifluorormethanesulfonic acid; borane; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; water;
DOI:10.1002/hlca.19870700204

Reference yield:

: 85026-06-8,5380-36-9,5380-37-0
(2S,3R)-3-methylmalic acid

: 111833-00-2
(2S,3S)-4-benzyloxy-2-hydroxy-3-methylbuttersaeure

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 1 h, r.t; 2.) 2 h, 60 deg C

2: 1.) 10 min, r.t; 2.) 1 h, 60 deg C

3: 85 percent / BH₃ / tetrahydrofuran / Ambient temperature

4: trifluoromethanesulfonic acid / cyclohexane; CH₂Cl₂ / 12 h / Ambient temperature

5: 74 percent / KOH / methanol; H₂O / Ambient temperature

With potassium hydroxide; trifluorormethanesulfonic acid; borane; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; water;
DOI:10.1002/hlca.19870700204