73840-71-8

Basic information

• Product Name: diethyl (2S,3R)-(+)-2-hydroxy-3-methylsuccinate
• Synonyms: diethyl (2S,3R)-(+)-2-hydroxy-3-methylsuccinate
• CAS NO: 73840-71-8
• Molecular Weight: 204.223
• Mol File: 73840-71-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl (2S,3R)-(+)-2-hydroxy-3-methylsuccinate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (2S,3R)-(+)-2-hydroxy-3-methylsuccinate(73840-71-8)
• EPA Substance Registry System: diethyl (2S,3R)-(+)-2-hydroxy-3-methylsuccinate(73840-71-8)

Safety Data

• Hazardous Substances Data: 73840-71-8(Hazardous Substances Data)

Upstream product

• 759-65-9 diethyl oxalpropionate 

Downstream Products

• 74243-90-6 (βS,4S)-β,2,3-trimethyl-1,3-dioxolane-4-ethanol p-toluenesulfonate 
• 80184-02-7 (2S,3S)-4-(benzyloxy)-3-methyl-1,2-butanediol 
• 88481-60-1 (4S,5S)-(4-Hydroxymethyl)-5-methyl-2-phenyl-1,3-dioxan 
• 85026-06-8 (2S,3R)-3-methylmalic acid 
• 111833-04-6 (2S,3S)-2-Acetoxy-4-benzyloxy-3-methyl-butyric acid methyl ester 
• 111833-00-2 (2S,3S)-4-benzyloxy-2-hydroxy-3-methylbuttersaeure 
• 344357-21-7 (3S,4R,3'R,4'S)-3-[3'-(4-methoxybenzyloxy)-4'-methylhexanoyl]-3-methoxymethyloxy-4-methyl-4-vinyl-γ-butyrolactone 
• 344357-26-2 (3R,4R,3'R,4'S)-3-[3'-(4-methoxybenzyloxy)-4'-methylhexanoyl]-3-methoxymethyloxy-4-methyl-4-vinyl-γ-butyrolactone 
• 344357-32-0 (S)-3-[(3R,4S)-1-Hydroxy-3-(4-methoxy-benzyloxy)-4-methyl-hexyl]-3-methoxymethoxy-4-methyl-4-vinyl-dihydro-furan-2-one 
• 344357-20-6 (3S,4R)-3-[3',3'-(ethylenedioxy)-3'-phenylpropanoyl]-3-methoxymethyloxy-4-methyl-4-vinyl-γ-butyrolactone 
• 344357-25-1 (3R,4R)-3-[3',3'-(ethylenedioxy)-3'-phenylpropanoyl]-3-methoxymethyloxy-4-methyl-4-vinyl-γ-butyrolactone 
• 344357-19-3 (S)-3-[1-Hydroxy-2-(2-phenyl-[1,3]dioxolan-2-yl)-ethyl]-3-methoxymethoxy-4-methyl-4-vinyl-dihydro-furan-2-one 
• 344357-31-9 (3S,4S)-3-methoxymethyloxy-4-methyl-4-[2-(2-nitrophenyl)seleno]-γ-butyrolactone 
• 344357-29-5 (2S,3R)-5-benzyloxy-3-ethoxycarbonyl-2-hydroxy-3-methylpentanoic acid 

Relevant articles and documents

Synthesis of erythro-2-Hydroxy-3-methylbutane-1,4-dioic Acid

Reduction of ethyl 3-methyl-2-oxobutane-1,4-dioate (3) with sodium borohydride furnishes a 6:1 mixture of ethyl erythro-2-hydroxy-3-methylbutane-1,4-dioate (8) and ethyl threo-2-hydroxy-3-methylbutane-1,4-dioate (18).Hydrolysis of this mixture with aq. hydrochloric acid gives a mixture of acids from which pure erythro-2-hydroxy-3-methylbutane-1,4-dioic acid (4) has been isolated.The stereochemistry of 4 has been establishrd by PMR and by transforming it to the anhydride, erythro-dihydro-3-acetyloxy-4-methyl-2,5-furandione (26).