(2S,3R,4S)-(4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol (-)-dibenzoyl-L-tartaric acid

Base Information

Chemical Name:(2S,3R,4S)-(4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol (-)-dibenzoyl-L-tartaric acid
CAS No.:1388651-04-4
Molecular Formula:C₁₈H₁₄O₈*C₃₁H₂₉F₂NO₃
Molecular Weight:859.877
Hs Code.:

Synonyms:(2S,3R,4S)-(4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol (-)-dibenzoyl-L-tartaric acid

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Chemical Property of (2S,3R,4S)-(4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol (-)-dibenzoyl-L-tartaric acid

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Technology Process of (2S,3R,4S)-(4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol (-)-dibenzoyl-L-tartaric acid

There total 11 articles about (2S,3R,4S)-(4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol (-)-dibenzoyl-L-tartaric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol

: 2743-38-6
O,O'-dibenzoyl-L-tartaric acid

: 1388651-04-4
(2S,3R,4S)-(4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol (-)-dibenzoyl-L-tartaric acid

Guidance literature:: In acetone; at 61.9 ℃; for 0.25h;

Reference yield:

: 1388651-35-1
(3aR*,4S*,6aS*)-6a-(2,3-difluorophenyl)-4-((trityloxy)methyl)hexahydrofuro[3,4-c]isoxazole

: 2743-38-6
O,O'-dibenzoyl-L-tartaric acid

: 1388651-04-4
(2S,3R,4S)-(4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol (-)-dibenzoyl-L-tartaric acid

Guidance literature:: In acetone; at 61.9 ℃; for 0.25h;

Reference yield:

: 76-83-5
trityl chloride

: 1388651-04-4
(2S,3R,4S)-(4-amino-4-(2,3-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol (-)-dibenzoyl-L-tartaric acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; triethylamine / toluene / 0 - 40 °C / Industry scale

2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / toluene; water / 0 - 15 °C

3.1: TurboGrignard / tetrahydrofuran / 0 - 10 °C / Inert atmosphere

3.2: 0 - 10 °C

4.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 - 35 °C

5.1: hydroquinone / toluene / 13 h / 110 - 115 °C

6.1: zinc; acetic acid / 15 - 18 °C

7.1: acetone / 0.25 h / 61.9 °C

With dmap; TurboGrignard; hydroxylamine hydrochloride; sodium acetate; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; triethylamine; hydroquinone; sodium hydroxide; zinc; In tetrahydrofuran; methanol; water; acetone; toluene;