di-O-butyl 6-O-benzyl-3-O-fluorenylmethoxycarbonyl-4-O-levulinoyl-2-deoxy-2-N-trichloroacetamidothio-β-D-galactopyranosylphosphate

Base Information

Chemical Name:di-O-butyl 6-O-benzyl-3-O-fluorenylmethoxycarbonyl-4-O-levulinoyl-2-deoxy-2-N-trichloroacetamidothio-β-D-galactopyranosylphosphate
CAS No.:1443018-85-6
Molecular Formula:C₄₃H₅₁Cl₃NO₁₃P
Molecular Weight:927.21
Hs Code.:

Synonyms:di-O-butyl 6-O-benzyl-3-O-fluorenylmethoxycarbonyl-4-O-levulinoyl-2-deoxy-2-N-trichloroacetamidothio-β-D-galactopyranosylphosphate

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Chemical Property of di-O-butyl 6-O-benzyl-3-O-fluorenylmethoxycarbonyl-4-O-levulinoyl-2-deoxy-2-N-trichloroacetamidothio-β-D-galactopyranosylphosphate

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Technology Process of di-O-butyl 6-O-benzyl-3-O-fluorenylmethoxycarbonyl-4-O-levulinoyl-2-deoxy-2-N-trichloroacetamidothio-β-D-galactopyranosylphosphate

There total 11 articles about di-O-butyl 6-O-benzyl-3-O-fluorenylmethoxycarbonyl-4-O-levulinoyl-2-deoxy-2-N-trichloroacetamidothio-β-D-galactopyranosylphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1557228-43-9
C₃₇H₃₈Cl₃NO₉S

: 107-66-4
dibutyl phosphate

: 1443018-85-6
di-O-butyl 6-O-benzyl-3-O-fluorenylmethoxycarbonyl-4-O-levulinoyl-2-deoxy-2-N-trichloroacetamidothio-β-D-galactopyranosylphosphate

Guidance literature:: C₃₇H₃₈Cl₃NO₉S; dibutyl phosphate; In dichloromethane; at 20 ℃; for 0.5h; Molecular sieve;

With N-iodo-succinimide; In dichloromethane; at -5 ℃; for 0.05h; Molecular sieve;

With trifluorormethanesulfonic acid; In dichloromethane; for 1h; Molecular sieve;
DOI:10.1039/c3cc48860h

Reference yield:

: 635684-80-9
ethyl 2-deoxy-2-N-trichloroacetamido-1-thio-β-D-glucopyranoside

: 1443018-85-6
di-O-butyl 6-O-benzyl-3-O-fluorenylmethoxycarbonyl-4-O-levulinoyl-2-deoxy-2-N-trichloroacetamidothio-β-D-galactopyranosylphosphate

Guidance literature:: Multi-step reaction with 7 steps

1.1: camphor-10-sulfonic acid / N,N-dimethyl-formamide / 4 h / 65 °C

2.1: pyridine / dichloromethane / 18 h / 20 °C

3.1: triethylsilane / dichloromethane / 0.5 h / 20 °C / Molecular sieve

3.2: 0 - 20 °C / Molecular sieve

4.1: pyridine / dichloromethane; 1,2-dichloro-ethane / 0.25 h / -10 °C

5.1: water / dichloromethane; 1,2-dichloro-ethane / 5 h / 80 °C

6.1: pyridine / dichloromethane / 4 h / 0 - 20 °C

7.1: dichloromethane / 0.5 h / 20 °C / Molecular sieve

7.2: 0.05 h / -5 °C / Molecular sieve

7.3: 1 h / Molecular sieve

With pyridine; triethylsilane; camphor-10-sulfonic acid; water; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc48860h

Reference yield:

: 1557228-38-2
ethyl 6-O-benzyl-3-O-levulinoyl-2-deoxy-2-N-trichloroacetamidothio-β-D-glucopyranoside

: 1443018-85-6
di-O-butyl 6-O-benzyl-3-O-fluorenylmethoxycarbonyl-4-O-levulinoyl-2-deoxy-2-N-trichloroacetamidothio-β-D-galactopyranosylphosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane; 1,2-dichloro-ethane / 0.25 h / -10 °C

2.1: water / dichloromethane; 1,2-dichloro-ethane / 5 h / 80 °C

3.1: pyridine / dichloromethane / 4 h / 0 - 20 °C

4.1: dichloromethane / 0.5 h / 20 °C / Molecular sieve

4.2: 0.05 h / -5 °C / Molecular sieve

4.3: 1 h / Molecular sieve

With pyridine; water; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1039/c3cc48860h