3-(3-benzyloxy-4-methoxyphenyl)-1-methyl-5-(pyrrolidin-1-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole

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Chemical Name:3-(3-benzyloxy-4-methoxyphenyl)-1-methyl-5-(pyrrolidin-1-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole
CAS No.:916735-58-5
Molecular Formula:C₂₇H₂₈N₄O₃
Molecular Weight:456.544
Hs Code.:

Synonyms:3-(3-benzyloxy-4-methoxyphenyl)-1-methyl-5-(pyrrolidin-1-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole

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Chemical Property of 3-(3-benzyloxy-4-methoxyphenyl)-1-methyl-5-(pyrrolidin-1-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole

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Technology Process of 3-(3-benzyloxy-4-methoxyphenyl)-1-methyl-5-(pyrrolidin-1-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole

There total 4 articles about 3-(3-benzyloxy-4-methoxyphenyl)-1-methyl-5-(pyrrolidin-1-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 74-88-4
methyl iodide

: 757188-97-9
3-(3-(benzyloxy-4-methoxyphenyl)-5-pyrrolidin-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole

: 916735-58-5
3-(3-benzyloxy-4-methoxyphenyl)-1-methyl-5-(pyrrolidin-1-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole

: 916735-59-6
5-(3-benzyloxy-4-methoxyphenyl)-1-methyl-3-(pyrrolidin-1-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.3987/COM-06-10824

Reference yield:

: 1699-39-4
2-(3-(benzyloxy)-4-methoxyphenyl)acetonitrile

: 916735-58-5
3-(3-benzyloxy-4-methoxyphenyl)-1-methyl-5-(pyrrolidin-1-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 62 percent / sodium ethoxide / ethanol / 0 °C

2.1: 4-chloropyridine hydrochloride / dioxane / 0.25 h

2.2: 83 percent / dioxane / Heating

3.1: 63 percent / 24 h / Heating

4.1: 41 percent / NaH / dimethylformamide / 12 h / 20 °C

With sodium ethanolate; 4-chlorpyridine hydrochloride; sodium hydride; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 2.1: Clauson-Kaas reaction;
DOI:10.3987/COM-06-10824

Reference yield:

: 757189-11-0
ethyl 4-amino-5-(3-benzyloxy-4-methoxyphenyl)-2H-pyrazole-3-carboxylate

: 916735-58-5
3-(3-benzyloxy-4-methoxyphenyl)-1-methyl-5-(pyrrolidin-1-ylcarbonyl)-4-(1H-pyrrol-1-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-chloropyridine hydrochloride / dioxane / 0.25 h

1.2: 83 percent / dioxane / Heating

2.1: 63 percent / 24 h / Heating

3.1: 41 percent / NaH / dimethylformamide / 12 h / 20 °C

With 4-chlorpyridine hydrochloride; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; 1.1: Clauson-Kaas reaction;
DOI:10.3987/COM-06-10824