N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide hydrochloride

Base Information

Chemical Name:N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide hydrochloride
CAS No.:1254069-36-7
Molecular Formula:C₂₀H₂₂N₄OS*ClH
Molecular Weight:402.948
Hs Code.:

Synonyms:N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide hydrochloride

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Chemical Property of N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide hydrochloride

Chemical Property:

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Technology Process of N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide hydrochloride

There total 10 articles about N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1254069-41-4
4-(3-methylsulfanyl-1-phenyl-1H-indazol-6-ylcarbamoyl)piperidine-1-carboxylicacid tert-butyl ester

: 1254069-36-7
N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/jm100677s

Reference yield:

: 1254069-37-8
6-nitro-1-phenyl-1,2-dihydroindazol-3-thione

: 1254069-36-7
N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 1 h / 10 °C

2: 5% Pd(II)/C(eggshell); hydrogen / ethyl acetate / 0.8 h / 20 °C

3: triethylamine; HATU / N,N-dimethyl-formamide / 2 h / 15 °C / Inert atmosphere

4: hydrogenchloride / dichloromethane / 0.5 h / 0 °C

With hydrogenchloride; 5% Pd(II)/C(eggshell); hydrogen; caesium carbonate; triethylamine; HATU; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm100677s

Reference yield:

: 63480-10-4
4-nitroisatoic anhydride

: 1254069-36-7
N-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperidine-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: ethanol / 0.08 h / Reflux

2: hydrogenchloride; sodium nitrite / tetrahydrofuran; ethanol; water / Reflux

3: tetraphosphorus decasulfide / 5,5-dimethyl-1,3-cyclohexadiene / 0.67 h / Reflux

4: caesium carbonate / acetonitrile / 1 h / 10 °C

5: 5% Pd(II)/C(eggshell); hydrogen / ethyl acetate / 0.8 h / 20 °C

6: triethylamine; HATU / N,N-dimethyl-formamide / 2 h / 15 °C / Inert atmosphere

7: hydrogenchloride / dichloromethane / 0.5 h / 0 °C

With hydrogenchloride; tetraphosphorus decasulfide; 5% Pd(II)/C(eggshell); hydrogen; caesium carbonate; triethylamine; HATU; sodium nitrite; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm100677s