1254069-41-4Relevant academic research and scientific papers
Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors
Zhang, Xuqing,Song, Fengbing,Kuo, Gee-Hong,Xiang, Amy,Gibbs, Alan C.,Abad, Marta C.,Sun, Weimei,Kuo, Lawrence C.,Sui, Zhihua
, p. 4762 - 4767 (2011/09/16)
A series of indazoles have been discovered as KHK inhibitors from a pyrazole hit identified through fragment-based drug discovery (FBDD). The optimization process guided by both X-ray crystallography and solution activity resulted in lead-like compounds with good pharmaceutical properties.
Electron density guided fragment-based lead discovery of ketohexokinase inhibitors
Gibbs, Alan C.,Abad, Marta C.,Zhang, Xuqing,Tounge, Brett A.,Lewandowski, Francis A.,Struble, Geoffrey T.,Sun, Weimei,Sui, Zhihua,Kuo, Lawrence C.
, p. 7979 - 7991 (2011/03/18)
A fragment-based drug design paradigm has been successfully applied in the discovery of lead series of ketohexokinase inhibitors. The paradigm consists of three iterations of design, synthesis, and X-ray crystallographic screening to progress low molecula
